FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765894939> ?p ?o ?g. }

• W2765894939 endingPage "3002" @default.
• W2765894939 startingPage "2990" @default.
• W2765894939 abstract "An array of homogeneous glycans representing all the major carbohydrate structures present in the cell wall of the human pathogen Mycobacterium tuberculosis and other mycobacteria has been probed with a panel of glycan-binding receptors expressed on cells of the mammalian innate immune system. The results provide an overview of interactions between mycobacterial glycans and receptors that mediate uptake and survival in macrophages, dendritic cells, and sinusoidal endothelial cells. A subset of the wide variety of glycan structures present on mycobacterial surfaces interact with cells of the innate immune system through the receptors tested. Endocytic receptors, including the mannose receptor, DC-SIGN, langerin, and DC-SIGNR (L-SIGN), interact predominantly with mannose-containing caps found on the mycobacterial polysaccharide lipoarabinomannan. Some of these receptors also interact with phosphatidyl-myo-inositol mannosides and mannose-containing phenolic glycolipids. Many glycans are ligands for overlapping sets of receptors, suggesting multiple, redundant routes by which mycobacteria can enter cells. Receptors with signaling capability interact with two distinct sets of mycobacterial glycans: targets for dectin-2 overlap with ligands for the mannose-binding endocytic receptors, while mincle binds exclusively to trehalose-containing structures such as trehalose dimycolate. None of the receptors surveyed bind furanose residues, which often form part of the epitopes recognized by antibodies to mycobacteria. Thus, the innate and adaptive immune systems can target different sets of mycobacterial glycans. This array, the first of its kind, represents an important new tool for probing, at a molecular level, biological roles of a broad range of mycobacterial glycans, a task that has not previously been possible." @default.
• W2765894939 created "2017-11-10" @default.
• W2765894939 creator A5009745231 @default.
• W2765894939 creator A5010476722 @default.
• W2765894939 creator A5011622872 @default.
• W2765894939 creator A5023295164 @default.
• W2765894939 creator A5024465369 @default.
• W2765894939 creator A5027636677 @default.
• W2765894939 creator A5028028831 @default.
• W2765894939 creator A5029015760 @default.
• W2765894939 creator A5043944767 @default.
• W2765894939 creator A5045411273 @default.
• W2765894939 creator A5046223826 @default.
• W2765894939 creator A5057961845 @default.
• W2765894939 creator A5062503370 @default.
• W2765894939 creator A5064613451 @default.
• W2765894939 creator A5086277029 @default.
• W2765894939 date "2017-11-03" @default.
• W2765894939 modified "2023-10-10" @default.
• W2765894939 title "Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans" @default.
• W2765894939 cites W1529358426 @default.
• W2765894939 cites W1554913609 @default.
• W2765894939 cites W1587492692 @default.
• W2765894939 cites W1660023118 @default.
• W2765894939 cites W1795113513 @default.
• W2765894939 cites W1814276120 @default.
• W2765894939 cites W1865996501 @default.
• W2765894939 cites W1873918295 @default.
• W2765894939 cites W1968830740 @default.
• W2765894939 cites W1984716857 @default.
• W2765894939 cites W1987194292 @default.
• W2765894939 cites W1987217273 @default.
• W2765894939 cites W1987517643 @default.
• W2765894939 cites W1988403716 @default.
• W2765894939 cites W1994763729 @default.
• W2765894939 cites W1995332691 @default.
• W2765894939 cites W2008163704 @default.
• W2765894939 cites W2012657759 @default.
• W2765894939 cites W2014029442 @default.
• W2765894939 cites W2027562913 @default.
• W2765894939 cites W2034949980 @default.
• W2765894939 cites W2035011417 @default.
• W2765894939 cites W2051336083 @default.
• W2765894939 cites W2061551128 @default.
• W2765894939 cites W2063945628 @default.
• W2765894939 cites W2076653230 @default.
• W2765894939 cites W2077594489 @default.
• W2765894939 cites W2082081313 @default.
• W2765894939 cites W2093678800 @default.
• W2765894939 cites W2093709579 @default.
• W2765894939 cites W2102609957 @default.
• W2765894939 cites W2105755414 @default.
• W2765894939 cites W2105952229 @default.
• W2765894939 cites W2110884049 @default.
• W2765894939 cites W2112998064 @default.
• W2765894939 cites W2113779347 @default.
• W2765894939 cites W2123888778 @default.
• W2765894939 cites W2124459085 @default.
• W2765894939 cites W2125278679 @default.
• W2765894939 cites W2131492616 @default.
• W2765894939 cites W2138032601 @default.
• W2765894939 cites W2139264590 @default.
• W2765894939 cites W2141706559 @default.
• W2765894939 cites W2142702165 @default.
• W2765894939 cites W2145729321 @default.
• W2765894939 cites W2149522811 @default.
• W2765894939 cites W2153548587 @default.
• W2765894939 cites W2154463442 @default.
• W2765894939 cites W2156643487 @default.
• W2765894939 cites W2156801938 @default.
• W2765894939 cites W2156875612 @default.
• W2765894939 cites W2158830057 @default.
• W2765894939 cites W2160831689 @default.
• W2765894939 cites W2169252930 @default.
• W2765894939 cites W2171159778 @default.
• W2765894939 cites W2198715944 @default.
• W2765894939 cites W2202888892 @default.
• W2765894939 cites W2327763024 @default.
• W2765894939 cites W2556744489 @default.
• W2765894939 cites W2558064835 @default.
• W2765894939 cites W2593652139 @default.
• W2765894939 cites W2727379302 @default.
• W2765894939 cites W918300749 @default.
• W2765894939 cites W2172091663 @default.
• W2765894939 doi "https://doi.org/10.1021/acschembio.7b00797" @default.
• W2765894939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5735379" @default.
• W2765894939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29048873" @default.
• W2765894939 hasPublicationYear "2017" @default.
• W2765894939 type Work @default.
• W2765894939 sameAs 2765894939 @default.
• W2765894939 citedByCount "59" @default.
• W2765894939 countsByYear W27658949392017 @default.
• W2765894939 countsByYear W27658949392018 @default.
• W2765894939 countsByYear W27658949392019 @default.
• W2765894939 countsByYear W27658949392020 @default.
• W2765894939 countsByYear W27658949392021 @default.
• W2765894939 countsByYear W27658949392022 @default.
• W2765894939 countsByYear W27658949392023 @default.

• next