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- W2765903776 abstract "Modifications of dietary protective or risk factors could be used to slow the progression of AD and/or delay its onset. However, factual data linking nutrition, metabolism and dementia are required. Preclinical studies provide an opportunity to study the impact of common nutrients on brain function in a controlled setting. Most of the focus has been on lipids and polyphenols, but amino acids can also impact brain health. Branched-chain amino acids (BCAA) are commonly used as dietary supplements to increase muscular mass. BCAA alters the ratios of amino acids transported into the brain, including precursors of monoamines, thereby impacting brain function. High levels of circulating BCAA are associated with metabolic risk factors of AD, but direct link with AD remains speculative. We thus investigated the impact of dietary BCAA on object recognition and neuropathological hallmarks of AD in an animal model. We have been using the 3xTg-AD model of Aβ/Tau neuropathology to determine the effects of nutraceutical interventions on cognitive performance and AD-like pathology. 3xTg-AD mice were fed either a control (CD) or a high-fat diet (HFD) from 6 to 16 months and then to high (+50%), normal (+0%) or low (-50%) BCAA intake from 16 to 18 months of age. Two-third of mice fed HFD supplemented in BCAA did not survive the 2-month treatment, possibly due to hepatic and muscle toxicity. In addition to increasing plasma BCAA, dietary BCAA treatment led to higher threonine, tryptophan and serotonin levels in the brain. Combining BCAA with high BCAA intake aggravated cortical tau pathology (insoluble tau pSer202/Thr205: +151%; soluble tau pSer202/Thr205: +271%; pThr231: +680%; pThr181: +93%), without affecting amyloid levels. Finally, mice on the low BCAA diets performed better at the novel object recognition task than mice on other diets." @default.
- W2765903776 created "2017-11-10" @default.
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- W2765903776 date "2017-07-01" @default.
- W2765903776 modified "2023-10-18" @default.
- W2765903776 title "[P4-362]: EFFECTS OF SPECIFIC NUTRIENTS ON COGNITION AND ALZHEIMER's DISEASE NEUROPATHOLOGY: THE CASE OF BRANCHED-CHAIN AMINO ACIDS (BCAA)" @default.
- W2765903776 doi "https://doi.org/10.1016/j.jalz.2017.06.2233" @default.
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