Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765904302> ?p ?o ?g. }
- W2765904302 abstract "Background: Low-intensity ultrasound (LIUS) was shown to be beneficial in mitigating inflammation and facilitating tissue repair in various pathologies. Determination of the molecular mechanisms underlying the anti-inflammatory effects of LIUS allows to optimize this technique as a therapy for the treatment of malignancies and aseptic inflammatory disorders. Methods: We conducted cutting-edge database mining approaches to determine the anti-inflammatory mechanisms exerted by LIUS. Results: Our data revealed following interesting findings: 1) LIUS anti-inflammatory effects are mediated by upregulating anti-inflammatory gene expression; 2) LIUS induces the upregulation of the markers and master regulators of immunosuppressor cells including MDSCs (myeloid-derived suppressor cells), MSCs (mesenchymal stem cells), B1-B cells and Treg (regulatory T cells); 3) LIUS not only can be used as a therapeutic approach to deliver drugs packed in various structures such as nanobeads, nanospheres, polymer microspheres, and lipidosomes, but also can make use of natural membrane vesicles as small as exosomes derived from immunosuppressor cells as a novel mechanism to fulfill its anti-inflammatory effects; 4) LIUS upregulates the expression of extracellular vesicle/ exosome biogenesis mediators and docking mediators; 5) Exosome-carried anti-inflammatory cytokines and anti-inflammatory microRNAs inhibit inflammation of target cells via multiple shared and specific pathways, suggesting exosome-mediated anti-inflammatory effect of LIUS feasible; and 6) LIUS-mediated physical effects on tissues may activate specific cellular sensors that activate downstream transcription factors and signaling pathways. Conclusions: Our results have provided novel insights into the mechanisms underlying anti-inflammatory effects of LIUS, and have provided guidance for the development of future novel therapeutic LIUS for cancers, inflammatory disorders, tissue regeneration and tissue repair." @default.
- W2765904302 created "2017-11-10" @default.
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- W2765904302 date "2017-10-23" @default.
- W2765904302 modified "2023-10-03" @default.
- W2765904302 title "Low-Intensity Ultrasound-Induced Anti-inflammatory Effects Are Mediated by Several New Mechanisms Including Gene Induction, Immunosuppressor Cell Promotion, and Enhancement of Exosome Biogenesis and Docking" @default.
- W2765904302 cites W1482244509 @default.
- W2765904302 cites W1494035906 @default.
- W2765904302 cites W1520693177 @default.
- W2765904302 cites W1567420244 @default.
- W2765904302 cites W1588408612 @default.
- W2765904302 cites W1762620449 @default.
- W2765904302 cites W1764435075 @default.
- W2765904302 cites W1816746890 @default.
- W2765904302 cites W1828045052 @default.
- W2765904302 cites W1837370850 @default.
- W2765904302 cites W1839129697 @default.
- W2765904302 cites W1874379912 @default.
- W2765904302 cites W1878889334 @default.
- W2765904302 cites W1886716828 @default.
- W2765904302 cites W1900474817 @default.
- W2765904302 cites W1969786757 @default.
- W2765904302 cites W1972114466 @default.
- W2765904302 cites W1972561586 @default.
- W2765904302 cites W1972870916 @default.
- W2765904302 cites W1973253766 @default.
- W2765904302 cites W1979056353 @default.
- W2765904302 cites W1985759884 @default.
- W2765904302 cites W1990973180 @default.
- W2765904302 cites W1995873025 @default.
- W2765904302 cites W1995945454 @default.
- W2765904302 cites W1997701240 @default.
- W2765904302 cites W2001555498 @default.
- W2765904302 cites W2004998372 @default.
- W2765904302 cites W2005173273 @default.
- W2765904302 cites W2006926663 @default.
- W2765904302 cites W2007037818 @default.
- W2765904302 cites W2008871739 @default.
- W2765904302 cites W2013299443 @default.
- W2765904302 cites W2014862659 @default.
- W2765904302 cites W2015387324 @default.
- W2765904302 cites W2015475721 @default.
- W2765904302 cites W2017014860 @default.
- W2765904302 cites W2017435508 @default.
- W2765904302 cites W2017532125 @default.
- W2765904302 cites W2018401472 @default.
- W2765904302 cites W2020914390 @default.
- W2765904302 cites W2028248159 @default.
- W2765904302 cites W2038802014 @default.
- W2765904302 cites W2039513919 @default.
- W2765904302 cites W2040836646 @default.
- W2765904302 cites W2045799105 @default.
- W2765904302 cites W2046551442 @default.
- W2765904302 cites W2064342194 @default.
- W2765904302 cites W2075214367 @default.
- W2765904302 cites W2076937557 @default.
- W2765904302 cites W2079400269 @default.
- W2765904302 cites W2089119446 @default.
- W2765904302 cites W2090138962 @default.
- W2765904302 cites W2090147784 @default.
- W2765904302 cites W2095364561 @default.
- W2765904302 cites W2098084846 @default.
- W2765904302 cites W2099315762 @default.
- W2765904302 cites W2105183438 @default.
- W2765904302 cites W2106072740 @default.
- W2765904302 cites W2109014876 @default.
- W2765904302 cites W2110599341 @default.
- W2765904302 cites W2114908158 @default.
- W2765904302 cites W2115690053 @default.
- W2765904302 cites W2118036576 @default.
- W2765904302 cites W2122403898 @default.
- W2765904302 cites W2122635106 @default.
- W2765904302 cites W2125266684 @default.
- W2765904302 cites W2135113543 @default.
- W2765904302 cites W2135425711 @default.
- W2765904302 cites W2136609880 @default.
- W2765904302 cites W2137634849 @default.
- W2765904302 cites W2138766402 @default.
- W2765904302 cites W2139050512 @default.
- W2765904302 cites W2143253053 @default.
- W2765904302 cites W2143265268 @default.
- W2765904302 cites W2152477743 @default.
- W2765904302 cites W2155366992 @default.
- W2765904302 cites W2159185120 @default.