FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765906618> ?p ?o ?g. }

• W2765906618 endingPage "1301" @default.
• W2765906618 startingPage "1292" @default.
• W2765906618 abstract "Abstract Rheumatoid arthritis ( RA ) is a chronic inflammatory disease characterized by joint swelling, joint tenderness and destruction of synovial joints, leading to severe disability. Anti‐inflammatory drugs and disease‐modifying anti‐rheumatic drugs ( DMARD s) may improve RA process. However, in most patients the treatment effect is still not satisfactory. Cyclin‐dependent kinase 7 (CDK7) plays a well‐established role in the regulation of the eukaryotic cell division cycle, and recent studies indicated that it exerted anti‐inflammatory effect. In our previous research, we found that inhibition of CDK 7 by highly selective inhibitor BS ‐181 significantly impeded the development of collagen‐induced arthritis ( CIA ) mice. However, the underlying mechanism of CDK 7 in RA remains to be explored. We elucidated the molecular mechanism of CDK 7 inhibition in RA inflammation by administration of CDK 7 highly selective inhibitor BS ‐181 and si RNA ‐ CDK 7. We found that both IL ‐1β, IL ‐6, IL ‐8 and RANKL transcript levels and IL ‐1β/ IL ‐6 secretion were effectively suppressed by BS ‐181 treatment as well as CDK 7 knockdown. Furthermore, CDK 7 inhibition prevented NF ‐κB signalling pathway activation and restrained p65 nuclear translocation. Moreover, CDK 7 selective inhibitor BS ‐181 also blocked phosphorylation of p65 in MH 7A cells. These results strongly indicate that CDK 7 inhibition by BS ‐181 and si RNA ‐ CDK 7 significantly suppresses rheumatoid arthritis inflammation, which may be via blockage of NF ‐κB signalling pathway and IL ‐1β/ IL ‐6 secretion." @default.
• W2765906618 created "2017-11-10" @default.
• W2765906618 creator A5004992023 @default.
• W2765906618 creator A5014642685 @default.
• W2765906618 creator A5022335283 @default.
• W2765906618 creator A5024417867 @default.
• W2765906618 creator A5030018306 @default.
• W2765906618 creator A5046341954 @default.
• W2765906618 creator A5046345736 @default.
• W2765906618 creator A5051065216 @default.
• W2765906618 creator A5075889094 @default.
• W2765906618 date "2017-10-30" @default.
• W2765906618 modified "2023-10-16" @default.
• W2765906618 title "CDK7 inhibition suppresses rheumatoid arthritis inflammation <i>via</i> blockage of NF-κB activation and IL-1β/IL-6 secretion" @default.
• W2765906618 cites W1563402960 @default.
• W2765906618 cites W1866332987 @default.
• W2765906618 cites W1967500525 @default.
• W2765906618 cites W1977451499 @default.
• W2765906618 cites W1997131908 @default.
• W2765906618 cites W1997925342 @default.
• W2765906618 cites W2006513975 @default.
• W2765906618 cites W2036902803 @default.
• W2765906618 cites W2039417635 @default.
• W2765906618 cites W2040474392 @default.
• W2765906618 cites W2042437382 @default.
• W2765906618 cites W2046628605 @default.
• W2765906618 cites W2049858249 @default.
• W2765906618 cites W2050175251 @default.
• W2765906618 cites W2062697678 @default.
• W2765906618 cites W2076357723 @default.
• W2765906618 cites W2079590652 @default.
• W2765906618 cites W2085248210 @default.
• W2765906618 cites W2087887322 @default.
• W2765906618 cites W2095013915 @default.
• W2765906618 cites W2112805169 @default.
• W2765906618 cites W2117486107 @default.
• W2765906618 cites W2121311666 @default.
• W2765906618 cites W2124343538 @default.
• W2765906618 cites W2128952811 @default.
• W2765906618 cites W2131017274 @default.
• W2765906618 cites W2136974788 @default.
• W2765906618 cites W2137866495 @default.
• W2765906618 cites W2149765709 @default.
• W2765906618 cites W2204697038 @default.
• W2765906618 cites W2297638727 @default.
• W2765906618 cites W2301131921 @default.
• W2765906618 cites W2509613909 @default.
• W2765906618 cites W2515697377 @default.
• W2765906618 cites W2527978347 @default.
• W2765906618 cites W2556607959 @default.
• W2765906618 cites W3022823009 @default.
• W2765906618 cites W4239057321 @default.
• W2765906618 doi "https://doi.org/10.1111/jcmm.13414" @default.
• W2765906618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5783872" @default.
• W2765906618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29083085" @default.
• W2765906618 hasPublicationYear "2017" @default.
• W2765906618 type Work @default.
• W2765906618 sameAs 2765906618 @default.
• W2765906618 citedByCount "15" @default.
• W2765906618 countsByYear W27659066182018 @default.
• W2765906618 countsByYear W27659066182019 @default.
• W2765906618 countsByYear W27659066182020 @default.
• W2765906618 countsByYear W27659066182021 @default.
• W2765906618 countsByYear W27659066182022 @default.
• W2765906618 countsByYear W27659066182023 @default.
• W2765906618 crossrefType "journal-article" @default.
• W2765906618 hasAuthorship W2765906618A5004992023 @default.
• W2765906618 hasAuthorship W2765906618A5014642685 @default.
• W2765906618 hasAuthorship W2765906618A5022335283 @default.
• W2765906618 hasAuthorship W2765906618A5024417867 @default.
• W2765906618 hasAuthorship W2765906618A5030018306 @default.
• W2765906618 hasAuthorship W2765906618A5046341954 @default.
• W2765906618 hasAuthorship W2765906618A5046345736 @default.
• W2765906618 hasAuthorship W2765906618A5051065216 @default.
• W2765906618 hasAuthorship W2765906618A5075889094 @default.
• W2765906618 hasBestOaLocation W27659066181 @default.
• W2765906618 hasConcept C104317684 @default.
• W2765906618 hasConcept C121608353 @default.
• W2765906618 hasConcept C124320809 @default.
• W2765906618 hasConcept C126322002 @default.
• W2765906618 hasConcept C173396325 @default.
• W2765906618 hasConcept C184235292 @default.
• W2765906618 hasConcept C185592680 @default.
• W2765906618 hasConcept C190283241 @default.
• W2765906618 hasConcept C203014093 @default.
• W2765906618 hasConcept C22615655 @default.
• W2765906618 hasConcept C2776914184 @default.
• W2765906618 hasConcept C2777077863 @default.
• W2765906618 hasConcept C2777575956 @default.
• W2765906618 hasConcept C2778298596 @default.
• W2765906618 hasConcept C29537977 @default.
• W2765906618 hasConcept C502942594 @default.
• W2765906618 hasConcept C55493867 @default.
• W2765906618 hasConcept C67705224 @default.
• W2765906618 hasConcept C71924100 @default.
• W2765906618 hasConcept C86803240 @default.
• W2765906618 hasConcept C95444343 @default.
• W2765906618 hasConcept C98274493 @default.

• next