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- W2765918099 abstract "Type 2 Diabetes Mellitus (T2DM) increases the risk of dementia. However, little is known as to whether T2DM is associated with decline in specific cognitive domains or brain atrophy. Participants were from the Cognition and Diabetes in Older Tasmanians study. Neuropsychological tests of processing speed, executive function and memory as well as Magnetic Resonance Imaging (MRI) were performed at baseline, 2.6 and 4.6 years. Multivariable mixed models were used to compare decline in cognition and brain atrophy over time in those with (n=349) and those without T2D (n=362) adjusting for age, sex and education, and for brain atrophy, total intracranial volume. The mean age of the sample was 70.0 (SD 7.4) years (range 55–90) with 56.% males. There were significant T2D×time interactions for tests of memory [the Hopkins Immediate (β-0.36 95%CI -0.55, -0.17 p<0.001) and the Hopkins Delay (β-0.13, 95%CI -0.22, -0.03; p=0.01)]; Attention [Digit span β-0.10 95%CI -0.21 -0.00; p=0.047] and executive function [COWAT category β -0.28 95% CI -0.43, -0.12 p=0.001], such that people with T2D demonstrated greater decline. There were no interactions (p>0.05) for tests of processing speed (digit symbol coding or symbol search) or inhibition (Stroop colour test). Although T2D was associated with smaller brain volumes at all time points (β-14133.7 95%CI -22045.67, -6221.722, p<0.001), there was no significant T2D×time interaction (p=0.58) for brain volume over time. In older people, T2D is associated with greater decline in cognition. It is possible that the effect of T2D on brain volumes begins earlier (midlife) and requires synergy with other neurodegenerative or vascular disease to accelerate decline at later age." @default.
- W2765918099 created "2017-11-10" @default.
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- W2765918099 date "2017-07-01" @default.
- W2765918099 modified "2023-09-27" @default.
- W2765918099 title "[P4-353]: LONGITUDINAL ASSOCIATIONS OF TYPE 2 DIABETES MELLITUS WITH COGNITIVE DECLINE AND BRAIN ATROPHY" @default.
- W2765918099 doi "https://doi.org/10.1016/j.jalz.2017.06.2224" @default.
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