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- W2765923361 abstract "Triple-negative breast cancer (TNBC) occurs in 10-15% of all breast cancer patients, yet it accounts for about half of all breast cancer deaths. There is an urgent need to identify new antitumor targets to provide additional treatment options for patients afflicted with this aggressive disease. Preclinical evidence suggests a critical role for insulin-like growth factor-2 (IGF2) and androgen receptor (AR) in regulating TNBC progression. To advance this work, a panel of TNBC cell lines was investigated with all cell lines showing significant expression of IGF2. Treatment with IGF2 stimulated cell proliferation in vitro (p < 0.05). Importantly, combination treatments with IGF1R inhibitors BMS-754807 and NVP-AEW541 elicited significant inhibition of TNBC cell proliferation (p < 0.001). Based on Annexin-V binding assays, BMS-754807, NVP-AEW541 and enzalutamide induced TNBC cell death (p < 0.005). Additionally, combination of enzalutamide with BMS-754807 or NVP-AEW541 exerted significant reductions in TNBC proliferation even in cells with low AR expression (p < 0.001). Notably, NVP-AEW541 and BMS-754807 reduced AR levels in BT549 TNBC cells. These results provide evidence that IGF2 promotes TNBC cell viability and proliferation, while inhibition of IGF1R/IR and AR pathways contribute to blockade of TNBC proliferation and promotion of apoptosis in vitro." @default.
- W2765923361 created "2017-11-10" @default.
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- W2765923361 date "2017-11-02" @default.
- W2765923361 modified "2023-10-18" @default.
- W2765923361 title "Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer" @default.
- W2765923361 cites W1580326294 @default.
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- W2765923361 cites W1656241491 @default.
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- W2765923361 cites W1839791863 @default.
- W2765923361 cites W1857266517 @default.
- W2765923361 cites W1861588860 @default.
- W2765923361 cites W1864088128 @default.
- W2765923361 cites W1969154275 @default.
- W2765923361 cites W1976263258 @default.
- W2765923361 cites W1989663680 @default.
- W2765923361 cites W1994104659 @default.
- W2765923361 cites W2003385907 @default.
- W2765923361 cites W2013132407 @default.
- W2765923361 cites W2016816289 @default.
- W2765923361 cites W2017536128 @default.
- W2765923361 cites W2018222101 @default.
- W2765923361 cites W2023241997 @default.
- W2765923361 cites W2026430211 @default.
- W2765923361 cites W2031253131 @default.
- W2765923361 cites W2045041545 @default.
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- W2765923361 cites W2063284702 @default.
- W2765923361 cites W2065352766 @default.
- W2765923361 cites W2071993616 @default.
- W2765923361 cites W2077945404 @default.
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- W2765923361 cites W2082484682 @default.
- W2765923361 cites W2085181480 @default.
- W2765923361 cites W2086519305 @default.
- W2765923361 cites W2088279063 @default.
- W2765923361 cites W2088874555 @default.
- W2765923361 cites W2095933146 @default.
- W2765923361 cites W2096900039 @default.
- W2765923361 cites W2108182027 @default.
- W2765923361 cites W2109600717 @default.
- W2765923361 cites W2111393163 @default.
- W2765923361 cites W2128327342 @default.
- W2765923361 cites W2134539328 @default.
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- W2765923361 cites W2138929540 @default.
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- W2765923361 cites W2165428941 @default.
- W2765923361 cites W2167400320 @default.
- W2765923361 cites W2175803345 @default.
- W2765923361 cites W2291265902 @default.
- W2765923361 cites W2430731787 @default.
- W2765923361 cites W2508062996 @default.
- W2765923361 cites W2523391168 @default.
- W2765923361 cites W2568986976 @default.
- W2765923361 cites W2590179977 @default.
- W2765923361 cites W2593628479 @default.
- W2765923361 cites W2605136418 @default.
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- W2765923361 doi "https://doi.org/10.3390/ijms18112305" @default.
- W2765923361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5713274" @default.
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- W2765923361 hasPublicationYear "2017" @default.
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