FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765932272> ?p ?o ?g. }

• W2765932272 endingPage "227" @default.
• W2765932272 startingPage "221" @default.
• W2765932272 abstract "We reported previously that Stachybotrys microspora triprenyl phenol-7 (SMTP-7) showed potential thrombolytic, anti-inflammatory and anti-oxidant effects that account for its excellent pharmacological activity such as having a wider therapeutic time window than tissue plasminogen activator (t-PA) and a significant protection against hemorrhage. The aim of the present study was to evaluate and compare the effect of a new series of SMTPs in the acetic acid-induced embolic cerebral infarct mouse model. Thrombotic occlusion was produced in mice by inducing the transfer of acetic acid-induced thrombi from the right common carotid artery into the brain. SMTPs were evaluated by their effect on reducing infarct area, neurological score and edema. Furthermore, plasmin formation, anti-inflammatory and anti-oxidant activities were assessed by fibrin zymography, measuring pro-inflammatory gene expression, and thiobarbituric acid reactive substances (TBARS) assay, respectively. Treatment with either SMTP-22 or SMTP-43 (10 mg/kg), which have similar plasmin formation, anti-inflammatory and anti-oxidant activities to SMTP-7, resulted in reduced infarct area, neurological score and edema. Coexistence of all these three activities appears to be important for the treatment of embolic infarction because SMTP-6, SMTP-25, and SMTP-44D (10 mg/kg), which are each missing at least one of the three functions, were not as effective. Therefore, these results indicate that SMTP-22 and SMTP-43 have potential as medicinal compounds for the treatment of embolic cerebral infarction." @default.
• W2765932272 created "2017-11-10" @default.
• W2765932272 creator A5006109788 @default.
• W2765932272 creator A5030805351 @default.
• W2765932272 creator A5044498054 @default.
• W2765932272 creator A5060734700 @default.
• W2765932272 creator A5088063434 @default.
• W2765932272 date "2018-01-01" @default.
• W2765932272 modified "2023-10-18" @default.
• W2765932272 title "Evaluation of the effects of a new series of SMTPs in the acetic acid-induced embolic cerebral infarct mouse model" @default.
• W2765932272 cites W1598217969 @default.
• W2765932272 cites W1933165727 @default.
• W2765932272 cites W1972723234 @default.
• W2765932272 cites W1973126805 @default.
• W2765932272 cites W1980074181 @default.
• W2765932272 cites W1980920937 @default.
• W2765932272 cites W1983256986 @default.
• W2765932272 cites W1997064745 @default.
• W2765932272 cites W1997188566 @default.
• W2765932272 cites W1998907224 @default.
• W2765932272 cites W2005035542 @default.
• W2765932272 cites W2030357150 @default.
• W2765932272 cites W2034447127 @default.
• W2765932272 cites W2038666492 @default.
• W2765932272 cites W2044636369 @default.
• W2765932272 cites W2048924576 @default.
• W2765932272 cites W2051543812 @default.
• W2765932272 cites W2056710646 @default.
• W2765932272 cites W2060147844 @default.
• W2765932272 cites W2075617449 @default.
• W2765932272 cites W2075984442 @default.
• W2765932272 cites W2079353155 @default.
• W2765932272 cites W2081856114 @default.
• W2765932272 cites W2084011551 @default.
• W2765932272 cites W2112505121 @default.
• W2765932272 cites W2125065061 @default.
• W2765932272 cites W2131547680 @default.
• W2765932272 cites W2138115734 @default.
• W2765932272 cites W2159154575 @default.
• W2765932272 cites W2159233098 @default.
• W2765932272 cites W2166342281 @default.
• W2765932272 cites W2168531927 @default.
• W2765932272 cites W2168831392 @default.
• W2765932272 cites W2292308933 @default.
• W2765932272 cites W2341972145 @default.
• W2765932272 cites W4250104750 @default.
• W2765932272 cites W4251423530 @default.
• W2765932272 doi "https://doi.org/10.1016/j.ejphar.2017.10.055" @default.
• W2765932272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29107671" @default.
• W2765932272 hasPublicationYear "2018" @default.
• W2765932272 type Work @default.
• W2765932272 sameAs 2765932272 @default.
• W2765932272 citedByCount "15" @default.
• W2765932272 countsByYear W27659322722018 @default.
• W2765932272 countsByYear W27659322722019 @default.
• W2765932272 countsByYear W27659322722020 @default.
• W2765932272 countsByYear W27659322722021 @default.
• W2765932272 countsByYear W27659322722022 @default.
• W2765932272 countsByYear W27659322722023 @default.
• W2765932272 crossrefType "journal-article" @default.
• W2765932272 hasAuthorship W2765932272A5006109788 @default.
• W2765932272 hasAuthorship W2765932272A5030805351 @default.
• W2765932272 hasAuthorship W2765932272A5044498054 @default.
• W2765932272 hasAuthorship W2765932272A5060734700 @default.
• W2765932272 hasAuthorship W2765932272A5088063434 @default.
• W2765932272 hasConcept C126322002 @default.
• W2765932272 hasConcept C181199279 @default.
• W2765932272 hasConcept C185592680 @default.
• W2765932272 hasConcept C203014093 @default.
• W2765932272 hasConcept C2776572282 @default.
• W2765932272 hasConcept C2776673659 @default.
• W2765932272 hasConcept C2779450755 @default.
• W2765932272 hasConcept C2780886150 @default.
• W2765932272 hasConcept C2781071845 @default.
• W2765932272 hasConcept C42219234 @default.
• W2765932272 hasConcept C54173615 @default.
• W2765932272 hasConcept C541997718 @default.
• W2765932272 hasConcept C55493867 @default.
• W2765932272 hasConcept C71924100 @default.
• W2765932272 hasConcept C98274493 @default.
• W2765932272 hasConceptScore W2765932272C126322002 @default.
• W2765932272 hasConceptScore W2765932272C181199279 @default.
• W2765932272 hasConceptScore W2765932272C185592680 @default.
• W2765932272 hasConceptScore W2765932272C203014093 @default.
• W2765932272 hasConceptScore W2765932272C2776572282 @default.
• W2765932272 hasConceptScore W2765932272C2776673659 @default.
• W2765932272 hasConceptScore W2765932272C2779450755 @default.
• W2765932272 hasConceptScore W2765932272C2780886150 @default.
• W2765932272 hasConceptScore W2765932272C2781071845 @default.
• W2765932272 hasConceptScore W2765932272C42219234 @default.
• W2765932272 hasConceptScore W2765932272C54173615 @default.
• W2765932272 hasConceptScore W2765932272C541997718 @default.
• W2765932272 hasConceptScore W2765932272C55493867 @default.
• W2765932272 hasConceptScore W2765932272C71924100 @default.
• W2765932272 hasConceptScore W2765932272C98274493 @default.
• W2765932272 hasFunder F4320318849 @default.
• W2765932272 hasFunder F4320320912 @default.
• W2765932272 hasLocation W27659322721 @default.

• next