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• W2765940114 abstract "The α-1 adrenoreceptor antagonist prazosin has shown promise in the treatment of post-traumatic stress disorder (PTSD) symptoms, but its mechanisms are not well understood. Here we administered prazosin or placebo prior to threat conditioning (day 1) and tested subsequent extinction (day 2) and reextinction (day 3) in healthy human participants. Prazosin did not affect threat conditioning but augmented stimulus discrimination during extinction and reextinction, via lower responding to the safe stimulus. These results suggest that prazosin during threat acquisition may have influenced encoding or consolidation of safety processing in particular, subsequently leading to enhanced discrimination between the safe and threatening stimuli." @default.
• W2765940114 created "2017-11-10" @default.
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• W2765940114 date "2017-10-16" @default.
• W2765940114 modified "2023-09-26" @default.
• W2765940114 title "Prazosin during threat discrimination boosts memory of the safe stimulus" @default.
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• W2765940114 doi "https://doi.org/10.1101/lm.045898.117" @default.
• W2765940114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5647929" @default.
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