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• W2765942110 abstract "Artemether is one of the most effective drugs for the treatment of chloroquine-resistant and Plasmodium falciparum strains of malaria. However, its therapeutic potency is hindered by its poor bioavailability. To overcome this limitation, we have encapsulated artemether in poly(lactic-co-glycolic) acid (PLGA) core–shell microparticles (MPs) using the coaxial electrospray method. With optimized process parameters including liquid flow rates and applied electric voltages, experiments are systematically carried out to generate a stable cone-jet mode to produce artemether-loaded PLGA-MPs with an average size of 2 μm, an encapsulation efficiency of 78 ± 5.6%, and a loading efficiency of 11.7%. The in vitro release study demonstrates the sustained release of artemether from the core–shell structure in comparison with that of plain artemether and that of MPs produced by single-axial electrospray without any relevant cytotoxicity. The in vivo studies are performed to evaluate the pharmacokinetic characteristics of the artemether-loaded PLGA-MPs. Our study implies that artemether can be effectively encapsulated in a protective shell of PLGA for controlled release kinetics and enhanced oral bioavailability." @default.
• W2765942110 created "2017-11-10" @default.
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• W2765942110 date "2017-11-14" @default.
• W2765942110 modified "2023-10-14" @default.
• W2765942110 title "Characteristics of Artemether-Loaded Poly(lactic-<i>co</i>-glycolic) Acid Microparticles Fabricated by Coaxial Electrospray: Validation of Enhanced Encapsulation Efficiency and Bioavailability" @default.
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• W2765942110 doi "https://doi.org/10.1021/acs.molpharmaceut.7b00862" @default.
• W2765942110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29096443" @default.
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