FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765943536> ?p ?o ?g. }

• W2765943536 endingPage "647.e6" @default.
• W2765943536 startingPage "635" @default.
• W2765943536 abstract "In the Drosophila immune response, bacterial derived diaminopimelic acid-type peptidoglycan binds the receptors PGRP-LC and PGRP-LE, which through interaction with the adaptor protein Imd leads to activation of the NF-κB homolog Relish and robust antimicrobial peptide gene expression. PGRP-LC, PGRP-LE, and Imd each contain a motif with some resemblance to the RIP Homotypic Interaction Motif (RHIM), a domain found in mammalian RIPK proteins forming functional amyloids during necroptosis. Here we found that despite sequence divergence, these Drosophila cryptic RHIMs formed amyloid fibrils in vitro and in cells. Amyloid formation was required for signaling downstream of Imd, and in contrast to the mammalian RHIMs, was not associated with cell death. Furthermore, amyloid formation constituted a regulatable step and could be inhibited by Pirk, an endogenous feedback regulator of this pathway. Thus, diverse sequence motifs are capable of forming amyloidal signaling platforms, and the formation of these platforms may present a regulatory point in multiple biological processes." @default.
• W2765943536 created "2017-11-10" @default.
• W2765943536 creator A5010227007 @default.
• W2765943536 creator A5015056220 @default.
• W2765943536 creator A5022803545 @default.
• W2765943536 creator A5026336429 @default.
• W2765943536 creator A5027728636 @default.
• W2765943536 creator A5027941815 @default.
• W2765943536 creator A5045129068 @default.
• W2765943536 creator A5057333378 @default.
• W2765943536 creator A5059666482 @default.
• W2765943536 creator A5069447518 @default.
• W2765943536 creator A5069451797 @default.
• W2765943536 creator A5075087392 @default.
• W2765943536 date "2017-10-01" @default.
• W2765943536 modified "2023-10-17" @default.
• W2765943536 title "Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling" @default.
• W2765943536 cites W1588296570 @default.
• W2765943536 cites W1588312796 @default.
• W2765943536 cites W1843274727 @default.
• W2765943536 cites W1941515972 @default.
• W2765943536 cites W1942992858 @default.
• W2765943536 cites W1955892023 @default.
• W2765943536 cites W1969238876 @default.
• W2765943536 cites W1970462135 @default.
• W2765943536 cites W1970577444 @default.
• W2765943536 cites W1973240345 @default.
• W2765943536 cites W1975511354 @default.
• W2765943536 cites W1976201852 @default.
• W2765943536 cites W1979032223 @default.
• W2765943536 cites W1980318479 @default.
• W2765943536 cites W1980927664 @default.
• W2765943536 cites W1982653993 @default.
• W2765943536 cites W1983151602 @default.
• W2765943536 cites W1984133423 @default.
• W2765943536 cites W1993211211 @default.
• W2765943536 cites W1993783912 @default.
• W2765943536 cites W1998983498 @default.
• W2765943536 cites W1999703939 @default.
• W2765943536 cites W2000399655 @default.
• W2765943536 cites W2000667679 @default.
• W2765943536 cites W2026457004 @default.
• W2765943536 cites W2032056947 @default.
• W2765943536 cites W2032208441 @default.
• W2765943536 cites W2032370476 @default.
• W2765943536 cites W2037270713 @default.
• W2765943536 cites W2043169858 @default.
• W2765943536 cites W2044178718 @default.
• W2765943536 cites W2048869977 @default.
• W2765943536 cites W2050598733 @default.
• W2765943536 cites W2051852947 @default.
• W2765943536 cites W2052104837 @default.
• W2765943536 cites W2052129538 @default.
• W2765943536 cites W2057246865 @default.
• W2765943536 cites W2061708393 @default.
• W2765943536 cites W2062202124 @default.
• W2765943536 cites W2071769633 @default.
• W2765943536 cites W2072179322 @default.
• W2765943536 cites W2076658768 @default.
• W2765943536 cites W2077906612 @default.
• W2765943536 cites W2078819049 @default.
• W2765943536 cites W2085899859 @default.
• W2765943536 cites W2096782178 @default.
• W2765943536 cites W2102549002 @default.
• W2765943536 cites W2110019438 @default.
• W2765943536 cites W2116428280 @default.
• W2765943536 cites W2116661167 @default.
• W2765943536 cites W2117537971 @default.
• W2765943536 cites W2117775547 @default.
• W2765943536 cites W2118038164 @default.
• W2765943536 cites W2120688918 @default.
• W2765943536 cites W2133375947 @default.
• W2765943536 cites W2137363142 @default.
• W2765943536 cites W2149077867 @default.
• W2765943536 cites W2149118112 @default.
• W2765943536 cites W2152278845 @default.
• W2765943536 cites W2152457344 @default.
• W2765943536 cites W2157250669 @default.
• W2765943536 cites W2327543693 @default.
• W2765943536 cites W2346575304 @default.
• W2765943536 cites W2502501643 @default.
• W2765943536 cites W2509997565 @default.
• W2765943536 cites W2604851831 @default.
• W2765943536 cites W2607664186 @default.
• W2765943536 cites W2618886652 @default.
• W2765943536 cites W4239137240 @default.
• W2765943536 doi "https://doi.org/10.1016/j.immuni.2017.09.011" @default.
• W2765943536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5665175" @default.
• W2765943536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29045898" @default.
• W2765943536 hasPublicationYear "2017" @default.
• W2765943536 type Work @default.
• W2765943536 sameAs 2765943536 @default.
• W2765943536 citedByCount "59" @default.
• W2765943536 countsByYear W27659435362017 @default.
• W2765943536 countsByYear W27659435362018 @default.
• W2765943536 countsByYear W27659435362019 @default.
• W2765943536 countsByYear W27659435362020 @default.
• W2765943536 countsByYear W27659435362021 @default.

• next