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• W2765944842 abstract "Abstract Background Optimal antibiotic prophylaxis duration in head and neck clean‐contaminated free‐flap cases is unknown. Methods A systematic review/meta‐analysis was conducted using PubMed/MEDLINE, Cochrane Library, Web‐of‐Science, and Scopus databases. Results Of the 3755 searched articles, 5 articles were included for a total of 861 patients. The recipient surgical site infection risk was significantly higher in patients receiving prophylactic antibiotics for ≤24 hours compared to >24 hours (relative risk [RR] 1.56; 95% confidence interval [CI] 1.13‐2.14). In the post hoc multivariate analysis based on available individual‐level data on 697 patients from 3 studies, the risk of surgical site infection for ≤24 hours versus >24 hours was not significant after adjusting for antibiotic type (RR 1.09; 95% CI 0.78‐1.55). When compared to ampicillin‐sulbactam, patients who received clindamycin prophylaxis had an increased likelihood of recipient surgical site infection (RR 2.85; 95% CI 1.95‐4.17). Conclusion Less than or equal to 24 hours of antibiotic prophylaxis in head and neck clean‐contaminated free‐flap is likely sufficient but a strong conclusion remains elusive. Clindamycin prophylaxis increases the risk of recipient surgical site infection. Further prospective trials are necessary to clarify." @default.
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• W2765944842 date "2017-10-30" @default.
• W2765944842 modified "2023-10-16" @default.
• W2765944842 title "Antibiotic prophylaxis in clean‐contaminated head and neck cases with microvascular free flap reconstruction: A systematic review and meta‐analysis" @default.
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• W2765944842 doi "https://doi.org/10.1002/hed.24988" @default.
• W2765944842 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6489503" @default.
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