FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765957454> ?p ?o ?g. }

• W2765957454 endingPage "107" @default.
• W2765957454 startingPage "98" @default.
• W2765957454 abstract "Abstract Therapeutic drug monitoring ( TDM ) could be helpful in oral targeted therapies. Data are sparse to evaluate its impact on treatment management. This study aimed to determine a threshold value of plasma drug exposure associated with the occurrence of grade 3–4 toxicity, then the potential impact of TDM on clinical decision. Consecutive outpatients treated with sunitinib were prospectively monitored between days 21 and 28 of the first cycle, then monthly until disease progression. At each consultation, the composite AUC Ƭ,ss (sunitinib + active metabolite SU 12662) was assayed. The decisions taken during each consultation were matched with AUC Ƭ,ss and compared to the decisional algorithm based on TDM . A total of 105 cancer patients and 288 consultations were matched with the closest AUC Ƭ,ss measurement. The majority (60%) of the patients had metastatic renal clear‐cell carcinoma (m RCC ). Fifty‐five (52%) patients experienced grade 3–4 toxicity. Multivariate analysis identified composite AUC Ƭ,ss as a parameter independently associated with grade 3–4 toxicity ( P < 0.0001). Using the ROC curve, the threshold value of composite AUC Ƭ,ss predicting grade ≥3 toxicity was 2150 ng/mL/h ( CI 95%, 0.6–0.79%; P < 0.0001). At disease progression in patients with m RCC , AUC Ƭ,ss tended to be lower than the one assayed during the first cycle (1678 vs. 2004 ng/mL/h, respectively, P = 0.072). TDM could have changed the medical decision for sunitinib dosing in 30% of patients at the first cycle of treatment, and in 46% of the patients over the whole treatment course. TDM is routinely feasible and may both contribute to improve toxicity management and to identify sunitinib underexposure at the time of disease progression." @default.
• W2765957454 created "2017-11-10" @default.
• W2765957454 creator A5002331357 @default.
• W2765957454 creator A5003647839 @default.
• W2765957454 creator A5010804968 @default.
• W2765957454 creator A5014962766 @default.
• W2765957454 creator A5015222370 @default.
• W2765957454 creator A5039428493 @default.
• W2765957454 creator A5060413020 @default.
• W2765957454 creator A5065121477 @default.
• W2765957454 creator A5067379430 @default.
• W2765957454 creator A5068650855 @default.
• W2765957454 creator A5086034709 @default.
• W2765957454 creator A5090375155 @default.
• W2765957454 creator A5090828621 @default.
• W2765957454 creator A5091487792 @default.
• W2765957454 date "2017-11-10" @default.
• W2765957454 modified "2023-10-09" @default.
• W2765957454 title "Drug monitoring of sunitinib in patients with advanced solid tumors: a monocentric observational French study" @default.
• W2765957454 cites W1946476244 @default.
• W2765957454 cites W1963900822 @default.
• W2765957454 cites W1976575396 @default.
• W2765957454 cites W1979748885 @default.
• W2765957454 cites W1984840953 @default.
• W2765957454 cites W1989153896 @default.
• W2765957454 cites W1994344097 @default.
• W2765957454 cites W2028754167 @default.
• W2765957454 cites W2043021219 @default.
• W2765957454 cites W2044254728 @default.
• W2765957454 cites W2047727316 @default.
• W2765957454 cites W2049145392 @default.
• W2765957454 cites W2083749767 @default.
• W2765957454 cites W2097955112 @default.
• W2765957454 cites W2113788015 @default.
• W2765957454 cites W2116949558 @default.
• W2765957454 cites W2117125017 @default.
• W2765957454 cites W2139511378 @default.
• W2765957454 cites W2149456801 @default.
• W2765957454 cites W2150615783 @default.
• W2765957454 cites W2152036882 @default.
• W2765957454 cites W2155319477 @default.
• W2765957454 cites W2158474413 @default.
• W2765957454 cites W2207224549 @default.
• W2765957454 cites W2728930563 @default.
• W2765957454 doi "https://doi.org/10.1111/fcp.12327" @default.
• W2765957454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29055166" @default.
• W2765957454 hasPublicationYear "2017" @default.
• W2765957454 type Work @default.
• W2765957454 sameAs 2765957454 @default.
• W2765957454 citedByCount "21" @default.
• W2765957454 countsByYear W27659574542018 @default.
• W2765957454 countsByYear W27659574542019 @default.
• W2765957454 countsByYear W27659574542020 @default.
• W2765957454 countsByYear W27659574542021 @default.
• W2765957454 countsByYear W27659574542022 @default.
• W2765957454 countsByYear W27659574542023 @default.
• W2765957454 crossrefType "journal-article" @default.
• W2765957454 hasAuthorship W2765957454A5002331357 @default.
• W2765957454 hasAuthorship W2765957454A5003647839 @default.
• W2765957454 hasAuthorship W2765957454A5010804968 @default.
• W2765957454 hasAuthorship W2765957454A5014962766 @default.
• W2765957454 hasAuthorship W2765957454A5015222370 @default.
• W2765957454 hasAuthorship W2765957454A5039428493 @default.
• W2765957454 hasAuthorship W2765957454A5060413020 @default.
• W2765957454 hasAuthorship W2765957454A5065121477 @default.
• W2765957454 hasAuthorship W2765957454A5067379430 @default.
• W2765957454 hasAuthorship W2765957454A5068650855 @default.
• W2765957454 hasAuthorship W2765957454A5086034709 @default.
• W2765957454 hasAuthorship W2765957454A5090375155 @default.
• W2765957454 hasAuthorship W2765957454A5090828621 @default.
• W2765957454 hasAuthorship W2765957454A5091487792 @default.
• W2765957454 hasBestOaLocation W27659574541 @default.
• W2765957454 hasConcept C112705442 @default.
• W2765957454 hasConcept C126322002 @default.
• W2765957454 hasConcept C143998085 @default.
• W2765957454 hasConcept C2777288759 @default.
• W2765957454 hasConcept C2777472916 @default.
• W2765957454 hasConcept C2779490328 @default.
• W2765957454 hasConcept C2780272996 @default.
• W2765957454 hasConcept C29730261 @default.
• W2765957454 hasConcept C71924100 @default.
• W2765957454 hasConcept C76318530 @default.
• W2765957454 hasConcept C90924648 @default.
• W2765957454 hasConceptScore W2765957454C112705442 @default.
• W2765957454 hasConceptScore W2765957454C126322002 @default.
• W2765957454 hasConceptScore W2765957454C143998085 @default.
• W2765957454 hasConceptScore W2765957454C2777288759 @default.
• W2765957454 hasConceptScore W2765957454C2777472916 @default.
• W2765957454 hasConceptScore W2765957454C2779490328 @default.
• W2765957454 hasConceptScore W2765957454C2780272996 @default.
• W2765957454 hasConceptScore W2765957454C29730261 @default.
• W2765957454 hasConceptScore W2765957454C71924100 @default.
• W2765957454 hasConceptScore W2765957454C76318530 @default.
• W2765957454 hasConceptScore W2765957454C90924648 @default.
• W2765957454 hasIssue "1" @default.
• W2765957454 hasLocation W27659574541 @default.
• W2765957454 hasLocation W27659574542 @default.
• W2765957454 hasOpenAccess W2765957454 @default.

• next