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- W2765964450 endingPage "150" @default.
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- W2765964450 abstract "Abstract PIWI-interacting RNAs (piRNAs) and associated proteins are primarily known to preserve genome integrity during germ cell development through silencing transposons. Recent research shows a much wider range of action of this pathway in germ and somatic cells. While there has been much progress, many questions about the fundamental mechanisms of the piRNA pathway including piRNA biogenesis, piRNA-binding partners and the functions of an increasing list of piRNA pathway–associated factors are still unresolved. The identification of specific piRNAs abundantly expressed in a variety of cancers and overexpression of piRNA pathway genes has established an important role of the piRNA pathway in the origin and progression of a variety of human malignancies. Here, we provide a brief introduction into the piRNA pathway and discuss recent evidence highlighting its importance in cancer biology." @default.
- W2765964450 created "2017-11-10" @default.
- W2765964450 creator A5035572752 @default.
- W2765964450 creator A5068533348 @default.
- W2765964450 creator A5080654765 @default.
- W2765964450 date "2018-01-01" @default.
- W2765964450 modified "2023-09-26" @default.
- W2765964450 title "PIWI-Interacting RNAs (piRNAs) and Cancer" @default.
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