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- W2765982694 abstract "The discovery of an ever-expanding plethora of coding and non-coding RNAs with nodal and causal roles in the regulation of lung physiology and disease is reinvigorating interest in the clinical utility of the oligonucleotide therapeutic class. This is strongly supported through recent advances in nucleic acids chemistry, synthetic oligonucleotide delivery and viral gene therapy that have succeeded in bringing to market at least three nucleic acid-based drugs. As a consequence, multiple new candidates such as RNA interference modulators, antisense, and splice switching compounds are now progressing through clinical evaluation. Here, manipulation of RNA for the treatment of lung disease is explored, with emphasis on robust pharmacological evidence aligned to the five pillars of drug development: exposure to the appropriate tissue, binding to the desired molecular target, evidence of the expected mode of action, activity in the relevant patient population and commercially viable value proposition." @default.
- W2765982694 created "2017-11-10" @default.
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- W2765982694 date "2017-10-01" @default.
- W2765982694 modified "2023-09-26" @default.
- W2765982694 title "Comet assay in rat lung, bronchoalveolar lavage (BAL) cells and nasal tissue, site of contact tissues in inhalation studies" @default.
- W2765982694 doi "https://doi.org/10.1016/j.toxlet.2017.07.282" @default.
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