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- W2765984953 abstract "Background and purpose Biomarker changes in cognitively impaired patients with small vessel disease are largely unknown. The rate of amyloid/lacune progression, cortical thinning and cognitive decline were evaluated in subcortical vascular mild cognitive impairment (svMCI) patients. Methods Seventy-two svMCI patients were divided into early stage (ES-svMCI, n = 39) and late stage (LS-svMCI, n = 33) according to their Clinical Dementia Rating Sum of Boxes score. Patients were annually followed up with neuropsychological tests and brain magnetic resonance imaging for 3 years, and underwent a second [11C] Pittsburgh compound B (PiB) positron emission tomography scan within a mean interval of 32.4 months. Results There was no difference in the rate of increase in PiB uptake or lacune number between the ES-svMCI and LS-svMCI. However, LS-svMCI showed more rapid cortical thinning and cognitive decline than did the ES-svMCI. Conclusions We suggest that, whilst the rate of change in pathological burden did not differ between ES-svMCI and LS-svMCI, cortical thinning and cognitive decline progressed more rapidly in the LS-svMCI." @default.
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- W2765984953 date "2017-12-21" @default.
- W2765984953 modified "2023-10-16" @default.
- W2765984953 title "Longitudinal cortical thinning and cognitive decline in patients with early‐ versus late‐stage subcortical vascular mild cognitive impairment" @default.
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- W2765984953 doi "https://doi.org/10.1111/ene.13500" @default.
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