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• W2765986404 abstract "Abstract Recently, we introduced a temperature sensitive Mycobacterium spp ., Mycobacterium paragordonae (Mpg). Here, we checked its potential as a candidate for live vaccination against Mycobacterium tuberculosis and Mycobacterium abscessus . Intravenous infections of mice with Mpg led to lower colony forming units (CFUs) compared to infection with BCG, suggesting its usefulness as a live vaccine. The analyses of immune responses indicated that the highly protective immunity elicited by Mpg was dependent on effective dendritic maturation, shift of cytokine patterns and antibody production toward a Th1 phenotype, and enhanced cytotoxic T cell response. Compared to BCG, Mpg showed a more effective protective immune response in the vaccinated mice against challenges with 2 different mycobacterial strains, M. tuberculosis H37Ra or M. abscessus Asan 50594. Our data suggest that a temperature sensitive Mpg may be a potentially powerful candidate vaccine strain to induce enhanced protective immune responses against M. tuberculosis and M. abscessus ." @default.
• W2765986404 created "2017-11-10" @default.
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• W2765986404 date "2017-11-09" @default.
• W2765986404 modified "2023-09-25" @default.
• W2765986404 title "A temperature sensitive Mycobacterium paragordonae induces enhanced protective immune responses against mycobacterial infections in the mouse model" @default.
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• W2765986404 doi "https://doi.org/10.1038/s41598-017-15458-7" @default.
• W2765986404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5680210" @default.
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