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- W2766007033 abstract "Abstract Rifampicin is a semi-synthetic drug derived from rifamycin B, and currently integrates the fixed dose combination tablet formulations used in the treatment of tuberculosis. It is also used in the leprosy polychemotherapy and prophylaxis, which are diseases classified as neglected according to the World Health Organization. Rifampicin is a polymorphic drug and its desirable polymorphic form is labeled as II, being the main goal of this study the elucidation of its crystalline structure. Polymorph II is characterized by two molecules with different conformations in the asymmetric unit and the following lattice parameters: a = 14.0760 (10) A, b = 17.5450 (10) A, c = 17.5270 (10) A, β = 92.15°. Differently to the previously reported structures, a charge transference from the hydroxyl group of the naphthoquinone of one conformer to the nitrogen of the piperazine group of the second conformer was observed. The relevance of the knowledge of this crystalline structure, which is the preferred polymorph for pharmaceutical formulations, was evidenced by analyzing raw materials with polymorphic mixtures. Thus, the results presented in this contribution close an old information gap allowing the complete solid-state characterization of rifampicin." @default.
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- W2766007033 date "2018-03-01" @default.
- W2766007033 modified "2023-10-06" @default.
- W2766007033 title "Crystalline structure of the marketed form of Rifampicin: a case of conformational and charge transfer polymorphism" @default.
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- W2766007033 doi "https://doi.org/10.1016/j.molstruc.2017.10.083" @default.
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