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• W2766035882 abstract "Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it was tentatively attributed to the chronic cytokine-mediated inflammatory response which was induced by dysregulation of HPA axis and overactivation of innate immunity. However, the exact mechanisms remain obscure. Herein, we mainly focused on the function of the NLRP3 inflammasome to investigate this issue.Male C57BL/6 mice were subjected to 12 weeks of chronic unpredictable mild stress (CUMS), some of which were injected with glyburide or fluoxetine. After CUMS procedure, behavioral and metabolic tests were carried out. In order to evaluate the systemic inflammation associated with inflammasome activation, IL-1β and inflammasome components in hippocampi and pancreases, as well as corticosterone and IL-1β in serum were detected separately. Moreover, immunostaining was performed to assess morphologic characteristics of pancreases.In the present study, we found that 12 weeks' chronic stress resulted in depressive-like behavior comorbid with insulin resistance. Furthermore, antidiabetic drug glyburide, an inhibitor of the NLRP3 inflammasome, was discovered to be effective in preventing the experimental comorbidity. In brief, it improved behavioral performance, ameliorated insulin intolerance as well as insulin signaling in the hippocampus possibly through inhibiting NLRP3 inflammasome activation by suppressing the expression of TXNIP.All these evidence supported our hypothesis that chronic stress led to comorbidity of depressive-like behavior and insulin resistance via long-term mild inflammation. More importantly, based on the beneficial effects of blocking the activation of the NLRP3 inflammasome, we provided a potential therapeutic target for clinical comorbidity and a new strategy for management of both diabetes and depression." @default.
• W2766035882 created "2017-11-10" @default.
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• W2766035882 date "2017-10-30" @default.
• W2766035882 modified "2023-10-18" @default.
• W2766035882 title "Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance" @default.
• W2766035882 cites W1807590635 @default.
• W2766035882 cites W1906422585 @default.
• W2766035882 cites W1948571728 @default.
• W2766035882 cites W1964744961 @default.
• W2766035882 cites W1965562132 @default.
• W2766035882 cites W1966344654 @default.
• W2766035882 cites W1967121645 @default.
• W2766035882 cites W1969216908 @default.
• W2766035882 cites W1969539443 @default.
• W2766035882 cites W1978666738 @default.
• W2766035882 cites W1989269954 @default.
• W2766035882 cites W2003862611 @default.
• W2766035882 cites W2005886168 @default.
• W2766035882 cites W2005900662 @default.
• W2766035882 cites W2018607502 @default.
• W2766035882 cites W2019629035 @default.
• W2766035882 cites W2020629155 @default.
• W2766035882 cites W2022155732 @default.
• W2766035882 cites W2024378513 @default.
• W2766035882 cites W2025410324 @default.
• W2766035882 cites W2034946303 @default.
• W2766035882 cites W2035667702 @default.
• W2766035882 cites W2040181124 @default.
• W2766035882 cites W2047234364 @default.
• W2766035882 cites W2051303794 @default.
• W2766035882 cites W2053963810 @default.
• W2766035882 cites W2055018912 @default.
• W2766035882 cites W2056973638 @default.
• W2766035882 cites W2059261698 @default.
• W2766035882 cites W2071844617 @default.
• W2766035882 cites W2085228888 @default.
• W2766035882 cites W2085881951 @default.
• W2766035882 cites W2089503694 @default.
• W2766035882 cites W2091064562 @default.
• W2766035882 cites W2098000380 @default.
• W2766035882 cites W2098914905 @default.
• W2766035882 cites W2103071544 @default.
• W2766035882 cites W2104205224 @default.
• W2766035882 cites W2107797783 @default.
• W2766035882 cites W2109356273 @default.
• W2766035882 cites W2110172023 @default.
• W2766035882 cites W2114058690 @default.
• W2766035882 cites W2124848390 @default.
• W2766035882 cites W2134007048 @default.
• W2766035882 cites W2134423240 @default.
• W2766035882 cites W2145910522 @default.
• W2766035882 cites W2148455993 @default.
• W2766035882 cites W2150702412 @default.
• W2766035882 cites W2155997356 @default.
• W2766035882 cites W2157240276 @default.
• W2766035882 cites W2157332070 @default.
• W2766035882 cites W2167354866 @default.
• W2766035882 cites W2174586285 @default.
• W2766035882 cites W2205259970 @default.
• W2766035882 cites W2224656707 @default.
• W2766035882 cites W2275191480 @default.
• W2766035882 cites W2306895579 @default.
• W2766035882 cites W2336378131 @default.
• W2766035882 cites W2337278592 @default.
• W2766035882 cites W2416643466 @default.
• W2766035882 cites W2417440151 @default.
• W2766035882 cites W2480966889 @default.
• W2766035882 cites W2488581011 @default.
• W2766035882 cites W2510719007 @default.
• W2766035882 cites W2513729692 @default.
• W2766035882 cites W2528385426 @default.
• W2766035882 cites W2537885802 @default.
• W2766035882 cites W2542571717 @default.
• W2766035882 cites W2563096962 @default.
• W2766035882 cites W2578653340 @default.
• W2766035882 cites W2587680743 @default.
• W2766035882 cites W2593489095 @default.
• W2766035882 cites W2605442678 @default.
• W2766035882 cites W2613289334 @default.
• W2766035882 cites W2656568860 @default.
• W2766035882 cites W2755329196 @default.
• W2766035882 cites W4242154469 @default.
• W2766035882 doi "https://doi.org/10.1186/s12974-017-0985-4" @default.
• W2766035882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5663104" @default.
• W2766035882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29084550" @default.
• W2766035882 hasPublicationYear "2017" @default.
• W2766035882 type Work @default.
• W2766035882 sameAs 2766035882 @default.

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