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- W2766039058 abstract "Poly(lactic acid) (PLA) and polysaccharide have been extensively studied for biomedical applications. However, the hydrophobicity of PLA makes it less desirable for cell adhesion, while dextran, a polysaccharide, is highly hydrophilic but its linear form is not very useful for tissue engineering because it readily dissolves in water. This study aimed to fabricate biodegradable cross-linked PLA-dextran nanofibrous scaffolds with tunable hydrophilicity and to test their effects on the attachment, differentiation and biological activities of mouse embryonic stem cells (ES cells). The cross-linked nanofibers of various compositions of PLA-g-dextran (10–88% dextran) were fabricated by grafting dextran onto PLA through maleic anhydride followed by co-axially reactive electrospinning with in situ photo-cross-linking of methacrylated dextran under UV irradiation. The results have shown that contact angles of electrospun PLA-g-dextran nanofibers decreased with increasing dextran content. The hydrophilic nanofibrous scaffolds containing 30% or 50% dextran can significantly enhance the attachment and differentiation of ES cells, which have demonstrated spontaneous contractions." @default.
- W2766039058 created "2017-11-10" @default.
- W2766039058 creator A5005507931 @default.
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- W2766039058 date "2017-12-01" @default.
- W2766039058 modified "2023-10-18" @default.
- W2766039058 title "Cross-linked poly(lactic acid)/dextran nanofibrous scaffolds with tunable hydrophilicity promoting differentiation of embryoid bodies" @default.
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- W2766039058 doi "https://doi.org/10.1016/j.mtcomm.2017.10.012" @default.
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