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- W2766045338 abstract "The vacuolar ATPase (V-ATPase) proton pump sustains cellular pH homeostasis, and its inhibition triggers numerous stress responses. However, the cellular mechanisms involved remain largely elusive in cancer cells. We studied V-ATPase in the prostate cancer (PCa) cell line PC-3, which has characteristics of highly metastatic PCa. V-ATPase inhibitors impaired endo-lysosomal pH, vesicle trafficking, migration, and invasion. V-ATPase accrual in the Golgi and recycling endosomes suggests that traffic of internalized membrane vesicles back to the plasma membrane was particularly impaired. Directed movement provoked co-localization of V-ATPase containing vesicles with F-actin near the leading edge of migrating cells. V-ATPase inhibition prompted prominent F-actin cytoskeleton reorganization. Filopodial projections were reduced, which related to reduced migration velocity. F-actin formed novel cytoplasmic rings. F-actin rings increased with extended exposure to sublethal concentrations of V-ATPase inhibitors, from 24 to 48 hours, as the amount of alkalinized endo-lysosomal vesicles increased. Studies with chloroquine indicated that F-actin rings formation was pH-dependent. We hypothesize that these novel F-actin rings assemble to overcome widespread traffic defects caused by V-ATPase inhibition, similar to F-actin rings on the surface of exocytic organelles." @default.
- W2766045338 created "2017-11-10" @default.
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- W2766045338 date "2017-01-01" @default.
- W2766045338 modified "2023-10-14" @default.
- W2766045338 title "F-actin reorganization by V-ATPase inhibition in prostate cancer" @default.
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- W2766045338 cites W1550067152 @default.
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- W2766045338 cites W1964414975 @default.
- W2766045338 cites W1971394915 @default.
- W2766045338 cites W1981166607 @default.
- W2766045338 cites W1984122112 @default.
- W2766045338 cites W1984736888 @default.
- W2766045338 cites W1985260515 @default.
- W2766045338 cites W1986263736 @default.
- W2766045338 cites W1990868556 @default.
- W2766045338 cites W1991555625 @default.
- W2766045338 cites W1994416882 @default.
- W2766045338 cites W1995862560 @default.
- W2766045338 cites W1998625200 @default.
- W2766045338 cites W2005471472 @default.
- W2766045338 cites W2005496979 @default.
- W2766045338 cites W2008618741 @default.
- W2766045338 cites W2011257151 @default.
- W2766045338 cites W2011911021 @default.
- W2766045338 cites W2016444704 @default.
- W2766045338 cites W2019012655 @default.
- W2766045338 cites W2019522696 @default.
- W2766045338 cites W2020529867 @default.
- W2766045338 cites W2025255158 @default.
- W2766045338 cites W2026773322 @default.
- W2766045338 cites W2029689680 @default.
- W2766045338 cites W2030677245 @default.
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- W2766045338 cites W2035501441 @default.
- W2766045338 cites W2039985150 @default.
- W2766045338 cites W2040000631 @default.
- W2766045338 cites W2042981232 @default.
- W2766045338 cites W2046776606 @default.
- W2766045338 cites W2051338141 @default.
- W2766045338 cites W2056138506 @default.
- W2766045338 cites W2058915875 @default.
- W2766045338 cites W2061369703 @default.
- W2766045338 cites W2062562477 @default.
- W2766045338 cites W2072307289 @default.
- W2766045338 cites W2074901596 @default.
- W2766045338 cites W2081409695 @default.
- W2766045338 cites W2083638799 @default.
- W2766045338 cites W2086564653 @default.
- W2766045338 cites W2090890940 @default.
- W2766045338 cites W2097695105 @default.
- W2766045338 cites W2104762821 @default.
- W2766045338 cites W2109662957 @default.
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- W2766045338 cites W2152462290 @default.
- W2766045338 cites W2154206349 @default.
- W2766045338 cites W2157176224 @default.
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- W2766045338 cites W2165089964 @default.
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- W2766045338 cites W2465929875 @default.
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- W2766045338 doi "https://doi.org/10.1242/bio.028837" @default.
- W2766045338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5703614" @default.
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- W2766045338 hasPublicationYear "2017" @default.
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