Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766064152> ?p ?o ?g. }
- W2766064152 endingPage "8" @default.
- W2766064152 startingPage "1" @default.
- W2766064152 abstract "Pain is a symptom shared by an incredible number of diseases. It is also one of the primary conditions that prompt individuals to seek medical treatment. Head and neck squamous cell carcinoma (HNSCC) corresponds to a heterogeneous disease that may arise from many distinct structures of a large, highly complex, and intricate region. HNSCC affects a great number of patients worldwide and is directly associated with chronic pain, which is especially prominent during the advanced stages of oral squamous cell carcinoma (OSCC), an anatomical and clinical subtype that corresponds to the great majority oral cancers. Although the cellular and molecular bases of oral cancer pain have not been fully established yet, the results of recent studies suggest that different epigenetic mechanisms may contribute to this process. For instance, there is strong scientific evidence that microRNAs (miRNAs), small RNA molecules that do not encode proteins, might act by regulating the mechanisms underlying cancer-related pain. Among the miRNAs that could possibly interfere in pain-signaling pathways, miR-125b, miR-181, and miR-339 emerge as some of the most promising candidates. In fact, such molecules apparently contribute to inflammatory pain. Moreover, these molecules possibly influence the activity of endogenous pain control systems (e.g., opioidergic and serotonergic systems), which could ultimately result in peripheral and central sensitization, central nervous system (CNS) phenomena innately associated with chronic pain. This review paper focuses on the current scientific knowledge regarding the involvement of miRNAs in cancer pain, with special attention dedicated to OSCC-related pain." @default.
- W2766064152 created "2017-11-10" @default.
- W2766064152 creator A5011144294 @default.
- W2766064152 creator A5038270845 @default.
- W2766064152 creator A5041182846 @default.
- W2766064152 creator A5047989183 @default.
- W2766064152 creator A5049209510 @default.
- W2766064152 creator A5075045063 @default.
- W2766064152 creator A5087405569 @default.
- W2766064152 creator A5087744018 @default.
- W2766064152 date "2017-01-01" @default.
- W2766064152 modified "2023-10-16" @default.
- W2766064152 title "miRNAs: Important Targets for Oral Cancer Pain Research" @default.
- W2766064152 cites W144423133 @default.
- W2766064152 cites W1687596153 @default.
- W2766064152 cites W1794955352 @default.
- W2766064152 cites W1826871104 @default.
- W2766064152 cites W1912143256 @default.
- W2766064152 cites W1918880456 @default.
- W2766064152 cites W1933460162 @default.
- W2766064152 cites W1963849020 @default.
- W2766064152 cites W1973903947 @default.
- W2766064152 cites W1979386195 @default.
- W2766064152 cites W1988469889 @default.
- W2766064152 cites W1990875610 @default.
- W2766064152 cites W1990958957 @default.
- W2766064152 cites W1996098543 @default.
- W2766064152 cites W1997658059 @default.
- W2766064152 cites W2001866502 @default.
- W2766064152 cites W2001951399 @default.
- W2766064152 cites W2003206209 @default.
- W2766064152 cites W2007766577 @default.
- W2766064152 cites W2009728729 @default.
- W2766064152 cites W2011047709 @default.
- W2766064152 cites W2012128092 @default.
- W2766064152 cites W2018482655 @default.
- W2766064152 cites W2018705639 @default.
- W2766064152 cites W2023940028 @default.
- W2766064152 cites W2024516936 @default.
- W2766064152 cites W2026601988 @default.
- W2766064152 cites W2040484651 @default.
- W2766064152 cites W2042735709 @default.
- W2766064152 cites W2044832480 @default.
- W2766064152 cites W2047146433 @default.
- W2766064152 cites W2049602848 @default.
- W2766064152 cites W2060868862 @default.
- W2766064152 cites W2064249847 @default.
- W2766064152 cites W2066965763 @default.
- W2766064152 cites W2070328448 @default.
- W2766064152 cites W2071358232 @default.
- W2766064152 cites W2072130793 @default.
- W2766064152 cites W2072565675 @default.
- W2766064152 cites W2075418919 @default.
- W2766064152 cites W2081432222 @default.
- W2766064152 cites W2083553342 @default.
- W2766064152 cites W2090781926 @default.
- W2766064152 cites W2094328854 @default.
- W2766064152 cites W2094500109 @default.
- W2766064152 cites W2096014620 @default.
- W2766064152 cites W2096756475 @default.
- W2766064152 cites W2098586449 @default.
- W2766064152 cites W2106299459 @default.
- W2766064152 cites W2107162857 @default.
- W2766064152 cites W2110675408 @default.
- W2766064152 cites W2114539862 @default.
- W2766064152 cites W2123074215 @default.
- W2766064152 cites W2126131804 @default.
- W2766064152 cites W2127432189 @default.
- W2766064152 cites W2129097062 @default.
- W2766064152 cites W2132239791 @default.
- W2766064152 cites W2141024484 @default.
- W2766064152 cites W2141757347 @default.
- W2766064152 cites W2144339761 @default.
- W2766064152 cites W2145859104 @default.
- W2766064152 cites W2146911993 @default.
- W2766064152 cites W2149166037 @default.
- W2766064152 cites W2156354702 @default.
- W2766064152 cites W2162466552 @default.
- W2766064152 cites W2167479375 @default.
- W2766064152 cites W2167670280 @default.
- W2766064152 cites W2190790361 @default.
- W2766064152 cites W2228189539 @default.
- W2766064152 cites W2257584443 @default.
- W2766064152 cites W2288651793 @default.
- W2766064152 cites W2327741866 @default.
- W2766064152 cites W2330679824 @default.
- W2766064152 cites W2398823158 @default.
- W2766064152 cites W2440189912 @default.
- W2766064152 cites W2515550007 @default.
- W2766064152 cites W2522862767 @default.
- W2766064152 cites W2581703858 @default.
- W2766064152 cites W2620876390 @default.
- W2766064152 cites W2626182247 @default.
- W2766064152 cites W2728356829 @default.
- W2766064152 cites W2951988944 @default.
- W2766064152 cites W4245145375 @default.
- W2766064152 doi "https://doi.org/10.1155/2017/4043516" @default.
- W2766064152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5682905" @default.