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- W2766095122 endingPage "2785" @default.
- W2766095122 startingPage "2768" @default.
- W2766095122 abstract "Williams' evolutionary theory of senescence based on antagonistic pleiotropy has become a landmark in evolutionary biology, and more recently in biogerontology and evolutionary medicine. In his original article, Williams launched a set of nine “testable deductions” from his theory. Although some of these predictions have been repeatedly discussed, most have been overlooked and no systematic evaluation of the whole set of Williams' original predictions has been performed. For the sixtieth anniversary of the publication of the Williams' article, we provide an updated evaluation of all these predictions. We present the pros and cons of each prediction based on recent accumulation of both theoretical and empirical studies performed in the laboratory and in the wild. From our viewpoint, six predictions are mostly supported by our current knowledge at least under some conditions (although Williams' theory cannot thoroughly explain why for some of them). Three predictions, all involving the timing of senescence, are not supported. Our critical review of Williams' predictions highlights the importance of William's contribution and clearly demonstrates that, 60 years after its publication, his article does not show any sign of senescence." @default.
- W2766095122 created "2017-11-10" @default.
- W2766095122 creator A5020896197 @default.
- W2766095122 creator A5064402913 @default.
- W2766095122 date "2017-11-30" @default.
- W2766095122 modified "2023-10-12" @default.
- W2766095122 title "The Williams' legacy: A critical reappraisal of his nine predictions about the evolution of senescence" @default.
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