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• W2766119543 abstract "Prolonged chemotherapy as well as rapid development of antimicrobial resistance are two of the major concerns for treatment of mycobacterial infections. To enhance the effectiveness of current drug regimens, search for compounds having synergistic interaction with anti-mycobacterial drugs has become indispensable. Here, we have investigated the intervention by oxidative stress, a major factor in mycobacterial pathogenesis, in combination with rifampicin (RIF), a first-line drug used against Mycobacterium tuberculosis. We have observed that a sub-inhibitory concentration of cumene hydroperoxide (CHP), a hydrophobic oxidant, synergistically reduced the minimum inhibitory concentration of RIF by fourfold, with a Fractional Inhibitory Concentration Index (FICI) of 0.45. Also, this interaction was found to be robust and synergistic against different strains of M. smegmatis as well as on M. bovis BCG, with FICI ranging from 0.3 to 0.6. Various physiological, biochemical and molecular parameters were explored to understand the mechanism of synergy. It was observed that increased membrane permeability owing to the presence of the oxidant, led to higher uptake of the drug. Moreover, downregulation of the hydroperoxide reductases by RIF, a transcriptional inhibitor, prevented quenching of the reactive oxygen species produced in the presence of CHP. The lipid soluble reactive species triggered autocatalytic lipid peroxidation (LPO), observed here as extensive membrane damage eventually leading to growth inhibition. Furthermore, it was seen that in combination with hydrogen peroxide (H2O2), the effect was only additive, establishing LPO as a key aspect leading toward synergism. To conclude, this work suggests that targeting the bacterial membrane by a radical species can have a significant impact on the treatment of tuberculosis." @default.
• W2766119543 created "2017-11-10" @default.
• W2766119543 creator A5048769684 @default.
• W2766119543 creator A5065418900 @default.
• W2766119543 date "2017-10-31" @default.
• W2766119543 modified "2023-10-17" @default.
• W2766119543 title "Synergistic Response of Rifampicin with Hydroperoxides on Mycobacterium: A Mechanistic Study" @default.
• W2766119543 cites W1518309486 @default.
• W2766119543 cites W1527805824 @default.
• W2766119543 cites W1669401314 @default.
• W2766119543 cites W1680748674 @default.
• W2766119543 cites W1755234803 @default.
• W2766119543 cites W1893039775 @default.
• W2766119543 cites W1904240753 @default.
• W2766119543 cites W19054850 @default.
• W2766119543 cites W1966478139 @default.
• W2766119543 cites W1969015249 @default.
• W2766119543 cites W1971668211 @default.
• W2766119543 cites W1979973356 @default.
• W2766119543 cites W1980009420 @default.
• W2766119543 cites W1982551127 @default.
• W2766119543 cites W1986402204 @default.
• W2766119543 cites W1990746686 @default.
• W2766119543 cites W1997684437 @default.
• W2766119543 cites W2000425923 @default.
• W2766119543 cites W2001364394 @default.
• W2766119543 cites W2002327125 @default.
• W2766119543 cites W2006195859 @default.
• W2766119543 cites W2007084462 @default.
• W2766119543 cites W2007467255 @default.
• W2766119543 cites W2009319388 @default.
• W2766119543 cites W2016562927 @default.
• W2766119543 cites W2018397292 @default.
• W2766119543 cites W2025422594 @default.
• W2766119543 cites W2025639892 @default.
• W2766119543 cites W2029681755 @default.
• W2766119543 cites W2036687082 @default.
• W2766119543 cites W2041134161 @default.
• W2766119543 cites W2041986564 @default.
• W2766119543 cites W2042039195 @default.
• W2766119543 cites W2042528022 @default.
• W2766119543 cites W2047871652 @default.
• W2766119543 cites W2048832265 @default.
• W2766119543 cites W2063859819 @default.
• W2766119543 cites W2068372433 @default.
• W2766119543 cites W2074503478 @default.
• W2766119543 cites W2077620426 @default.
• W2766119543 cites W2081791485 @default.
• W2766119543 cites W2084171643 @default.
• W2766119543 cites W2084556018 @default.
• W2766119543 cites W2087198337 @default.
• W2766119543 cites W2090569773 @default.
• W2766119543 cites W2098968714 @default.
• W2766119543 cites W2100266438 @default.
• W2766119543 cites W2111524961 @default.
• W2766119543 cites W2113001906 @default.
• W2766119543 cites W2115984022 @default.
• W2766119543 cites W2118057304 @default.
• W2766119543 cites W2118995881 @default.
• W2766119543 cites W2124765964 @default.
• W2766119543 cites W2127258416 @default.
• W2766119543 cites W2128079705 @default.
• W2766119543 cites W2133723544 @default.
• W2766119543 cites W2136931384 @default.
• W2766119543 cites W2140981202 @default.
• W2766119543 cites W2142705616 @default.
• W2766119543 cites W2147173298 @default.
• W2766119543 cites W2147601640 @default.
• W2766119543 cites W2155076068 @default.
• W2766119543 cites W2171251768 @default.
• W2766119543 cites W2173151789 @default.
• W2766119543 cites W2178656605 @default.
• W2766119543 cites W2183288990 @default.
• W2766119543 cites W2240633951 @default.
• W2766119543 cites W2314281782 @default.
• W2766119543 cites W233147817 @default.
• W2766119543 cites W2337035229 @default.
• W2766119543 cites W2340847980 @default.
• W2766119543 cites W2466695991 @default.
• W2766119543 cites W2512046283 @default.
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• W2766119543 doi "https://doi.org/10.3389/fmicb.2017.02075" @default.
• W2766119543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5671503" @default.
• W2766119543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29163385" @default.
• W2766119543 hasPublicationYear "2017" @default.
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