FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766125466> ?p ?o ?g. }

• W2766125466 endingPage "e0187561" @default.
• W2766125466 startingPage "e0187561" @default.
• W2766125466 abstract "Endoplasmic reticulum (ER) stress is characterized by the accumulation of misfolded proteins due to an impairment of ER quality control pathways leading to the activation of a defense system, called unfolded protein response (UPR). While thyrocytes are supposed to be highly susceptible to environmental conditions that cause ER stress due to the synthesis of large amounts of secretory proteins required for thyroid hormone synthesis, systematic investigations on the effect of ER stress on expression of key genes of thyroid hormone synthesis and their transcriptional regulators are lacking. Since the aim of the ER stress-induced UPR is to restore ER homeostasis and to facilitate cell survival through transient shutdown of ribosomal protein translation, we hypothesized that the expression of genes involved in thyroid hormone synthesis and their transcriptional regulators, all of which are not essential for cell survival, are down-regulated in thyrocytes during ER stress, while sterol regulatory element-binding proteins (SREBPs) are activated during ER stress in thyrocytes. Treatment of FRTL-5 thyrocytes with the ER stress inducer tunicamycin (TM) dose-dependently increased the mRNA and/or protein levels of known UPR target genes, stimulated phosphorylation of the ER stress sensor protein kinase RNA-like ER kinase (PERK) and of the PERK target protein eukaryotic initiation factor 2α (eIF2α) and caused splicing of the ER stress-sensitive transcription factor X-box binding protein (XBP-1) (P < 0.05). The mRNA levels and/or protein levels of genes involved in thyroid hormone synthesis, sodium/iodide symporter (NIS), thyroid peroxidase (TPO) and thyroglobulin (TG), their transcriptional regulators and thyrotropin (TSH) receptor and the uptake of Na125I were reduced at the highest concentration of TM tested (0.1 μg/mL; P < 0.05). Proteolytic activation of the SREBP-1c pathway was not observed in FRTL-5 cells treated with TM, whereas TM reduced proteolytic activation of the SREBP-2 pathway at 0.1 μg TM/mL (P < 0.05). In conclusion, the expression of key genes involved in thyroid hormone synthesis and their critical regulators and of the TSH receptor as well as the uptake of iodide is attenuated in thyrocytes during mild ER stress. Down-regulation of NIS, TPO and TG during ER stress is likely the consequence of impaired TSH/TSHR signaling in concert with reduced expression of critical transcriptional regulators of these genes." @default.
• W2766125466 created "2017-11-10" @default.
• W2766125466 creator A5030594645 @default.
• W2766125466 creator A5049087441 @default.
• W2766125466 creator A5053237065 @default.
• W2766125466 date "2017-11-02" @default.
• W2766125466 modified "2023-10-06" @default.
• W2766125466 title "Endoplasmic reticulum stress inhibits expression of genes involved in thyroid hormone synthesis and their key transcriptional regulators in FRTL-5 thyrocytes" @default.
• W2766125466 cites W1493370386 @default.
• W2766125466 cites W1499500424 @default.
• W2766125466 cites W1524836399 @default.
• W2766125466 cites W1541004586 @default.
• W2766125466 cites W1577577364 @default.
• W2766125466 cites W167285632 @default.
• W2766125466 cites W1685138608 @default.
• W2766125466 cites W1764928462 @default.
• W2766125466 cites W1773909942 @default.
• W2766125466 cites W178670659 @default.
• W2766125466 cites W1970946441 @default.
• W2766125466 cites W1985478480 @default.
• W2766125466 cites W1985579269 @default.
• W2766125466 cites W1988364921 @default.
• W2766125466 cites W1988740497 @default.
• W2766125466 cites W1994772574 @default.
• W2766125466 cites W1996785501 @default.
• W2766125466 cites W1999711588 @default.
• W2766125466 cites W2003755766 @default.
• W2766125466 cites W2007631927 @default.
• W2766125466 cites W2011721908 @default.
• W2766125466 cites W2014556626 @default.
• W2766125466 cites W2024475665 @default.
• W2766125466 cites W2031962983 @default.
• W2766125466 cites W2041989129 @default.
• W2766125466 cites W2048184523 @default.
• W2766125466 cites W2051405784 @default.
• W2766125466 cites W2055043387 @default.
• W2766125466 cites W2055290156 @default.
• W2766125466 cites W2055490433 @default.
• W2766125466 cites W2059080130 @default.
• W2766125466 cites W2062378136 @default.
• W2766125466 cites W2062918974 @default.
• W2766125466 cites W2070803483 @default.
• W2766125466 cites W2078039611 @default.
• W2766125466 cites W2082900804 @default.
• W2766125466 cites W2089198803 @default.
• W2766125466 cites W2093158584 @default.
• W2766125466 cites W2107948640 @default.
• W2766125466 cites W2110113462 @default.
• W2766125466 cites W2115793941 @default.
• W2766125466 cites W2118836236 @default.
• W2766125466 cites W2120736516 @default.
• W2766125466 cites W2122957192 @default.
• W2766125466 cites W2125570287 @default.
• W2766125466 cites W2127906377 @default.
• W2766125466 cites W2130326770 @default.
• W2766125466 cites W2134499735 @default.
• W2766125466 cites W2146544786 @default.
• W2766125466 cites W2147102436 @default.
• W2766125466 cites W2155544618 @default.
• W2766125466 cites W2165554981 @default.
• W2766125466 cites W2171194384 @default.
• W2766125466 cites W2192080449 @default.
• W2766125466 cites W2286062426 @default.
• W2766125466 cites W2312414558 @default.
• W2766125466 cites W2466957550 @default.
• W2766125466 cites W2510362565 @default.
• W2766125466 cites W2626574496 @default.
• W2766125466 cites W2966412521 @default.
• W2766125466 cites W4252021281 @default.
• W2766125466 doi "https://doi.org/10.1371/journal.pone.0187561" @default.
• W2766125466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5667865" @default.
• W2766125466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29095946" @default.
• W2766125466 hasPublicationYear "2017" @default.
• W2766125466 type Work @default.
• W2766125466 sameAs 2766125466 @default.
• W2766125466 citedByCount "22" @default.
• W2766125466 countsByYear W27661254662018 @default.
• W2766125466 countsByYear W27661254662019 @default.
• W2766125466 countsByYear W27661254662020 @default.
• W2766125466 countsByYear W27661254662021 @default.
• W2766125466 countsByYear W27661254662022 @default.
• W2766125466 countsByYear W27661254662023 @default.
• W2766125466 crossrefType "journal-article" @default.
• W2766125466 hasAuthorship W2766125466A5030594645 @default.
• W2766125466 hasAuthorship W2766125466A5049087441 @default.
• W2766125466 hasAuthorship W2766125466A5053237065 @default.
• W2766125466 hasBestOaLocation W27661254661 @default.
• W2766125466 hasConcept C126322002 @default.
• W2766125466 hasConcept C139447449 @default.
• W2766125466 hasConcept C153911025 @default.
• W2766125466 hasConcept C158617107 @default.
• W2766125466 hasConcept C184235292 @default.
• W2766125466 hasConcept C185592680 @default.
• W2766125466 hasConcept C2777575526 @default.
• W2766125466 hasConcept C2778997996 @default.
• W2766125466 hasConcept C3675279 @default.
• W2766125466 hasConcept C71924100 @default.
• W2766125466 hasConcept C86803240 @default.

• next