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- W2766133073 abstract "Clearance of amyloid-beta (Aβ) in the brain is an important therapeutic strategy for Alzheimer's disease (AD). Current studies mainly focus on the central approach of Aβ clearance by introducing therapeutic agents into the brain. Our previous study found that peripheral tissues and organs play important roles in clearing brain-derived Aβ, suggesting that the peripheral approach by removing Aβ from blood may also effective for AD therapy. Here, we aimed to investigate whether peritoneal dialysis (PD), which is a clinically available therpeutic method, is able to reduce brain Aβ burden and attenuate AD-type pathologies and behavioral deficits in an APP/PS1 mouse model. The plasma Aβ concentrations of patients with chonic renal failure (CRF) were measured before and after PD. APP/PS1 mice were subjected to PD once a day for one month from 6 months of age (prevention study) or 9 months of age (treatment study). Aβ in interstitial fluid (ISF) were collected using microdialysis. Behavioral performance, Long-term potentiation (LTP), Aβ burden and other AD-type pathologies were measured after one-month PD. PD significantly reduced plasma Aβ levels in both patients with CRF and APP/PS1 mice. Aβ levels in ISF of APP/PS1 mice decreased immediately after the decrease of Aβ in blood during PD. In both prevention and treatment studies, PD substantially reduced Aβ deposition, attenuated other AD-type pathologies including Tau hyperphosphorylation, glial activation, neuroinflammation, neuronal loss, synaptic dysfunction, and rescued the behavioral deficits of APPswe/PS1 mice. Importantly, Aβ phagocytosis function of microglia was enhanced in APP/PS1 mice after PD. PD is a promising therapeutic method for AD. Peripheral approach of Aβ clearance would be a desirable therapeutic strategy for AD." @default.
- W2766133073 created "2017-11-10" @default.
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- W2766133073 date "2017-07-01" @default.
- W2766133073 modified "2023-10-16" @default.
- W2766133073 title "[O4-06-02]: PERITONEAL DIALYSIS REDUCES AMYLOID-BETA BURDEN AND ATTENUATES AD-TYPE PATHOLOGIES IN THE BRAIN OF AN APP/PS1 MOUSE MODEL" @default.
- W2766133073 doi "https://doi.org/10.1016/j.jalz.2017.07.449" @default.
- W2766133073 hasPublicationYear "2017" @default.
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