Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766165445> ?p ?o ?g. }
- W2766165445 abstract "Significance Functionally diverse enzyme superfamilies are sets of homologs that conserve a structural fold and mechanistic details but perform various distinct chemical reactions. What are the evolutionary routes by which ancestral proteins diverge to produce extant enzymes? We present an approach that combines experimental data with computational tools to trace these sequence–structure–function transitions in a model system, the functionally diverse flavin mononucleotide-dependent nitroreductases (NTRs). Our results suggest an evolutionary model in which contemporary NTR classes have diverged in a radial manner from a minimal flavin-binding scaffold via insertions at key positions and fixation of functional residues, yielding the reaction versatility of contemporary enzymes. These principles will facilitate rational design of NTRs and advance general approaches for delineating the emergence of functional diversity in enzyme superfamilies." @default.
- W2766165445 created "2017-11-10" @default.
- W2766165445 creator A5020002876 @default.
- W2766165445 creator A5057060807 @default.
- W2766165445 creator A5063726641 @default.
- W2766165445 creator A5088580694 @default.
- W2766165445 date "2017-10-24" @default.
- W2766165445 modified "2023-10-12" @default.
- W2766165445 title "Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily" @default.
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