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- W2766176052 abstract "A priority for biomedical research is to understand the causes of variation in susceptibility to infection. To investigate genetic variation in a model system, we used flies collected from single populations of three different species of Drosophila and artificially selected them for resistance to the parasitoid wasp Leptopilina boulardi, and found that survival rates increased 3 to 30 fold within 6 generations. Resistance in all three species involves a large increase in the number of the circulating hemocytes that kill parasitoids. However, the different species achieve this in different ways, with D. melanogaster moving sessile hemocytes into circulation while the other species simply produce more cells. Therefore, the convergent evolution of the immune phenotype has different developmental bases. These changes are costly, as resistant populations of all three species had greatly reduced larval survival. In all three species resistance is only costly when food is in short supply, and resistance was rapidly lost from D. melanogaster populations when food is restricted. Furthermore, evolving resistance to L. boulardi resulted in cross-resistance against other parasitoids. Therefore, whether a population evolves resistance will depend on ecological conditions including food availability and the presence of different parasite species." @default.
- W2766176052 created "2017-11-10" @default.
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- W2766176052 date "2017-10-19" @default.
- W2766176052 modified "2023-10-14" @default.
- W2766176052 title "Parallel and costly changes to cellular immunity underlie the evolution of parasitoid resistance in three Drosophila species" @default.
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- W2766176052 doi "https://doi.org/10.1371/journal.ppat.1006683" @default.
- W2766176052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5663624" @default.
- W2766176052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29049362" @default.
- W2766176052 hasPublicationYear "2017" @default.
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