Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766194804> ?p ?o ?g. }
- W2766194804 endingPage "242" @default.
- W2766194804 startingPage "239" @default.
- W2766194804 abstract "Mycotoxins, including zearalenone (ZEA), can occur worldwide in cereals. They can enter the food chain and cause several health disorders. ZEA and its derivatives (α-zearalenol, α-ZOL and β-zearalenol, β-ZOL) have structural analogy to estrogen, thus they can bind to estrogen receptors (ERs). In order to characterize the estrogenic activity of ZEA, α-ZOL and β-ZOL, the proliferation of ER-positive human breast cancer cells (MCF-7) exposed to these mycotoxins was measured. After exposure at levels ranging from 6.25 to 25 µM, cell proliferation was evaluated by using the E-Screen bioassay. In accordance with previous studies, our results show the estrogenic activity of ZEA, α-ZOL and β-ZOL in MCF-7 cells. This effect is related to ZEA and its metabolites being flexible enough to bind to mammalian ERs. The relative proliferative effect (RPE) ranged from 10% to 91%. The α-ZOL induced the highest proliferative effect due to its higher affinity for the ERs compared to the other mycotoxins." @default.
- W2766194804 created "2017-11-10" @default.
- W2766194804 creator A5006350016 @default.
- W2766194804 creator A5019423761 @default.
- W2766194804 creator A5038253965 @default.
- W2766194804 creator A5054690504 @default.
- W2766194804 date "2017-11-10" @default.
- W2766194804 modified "2023-10-06" @default.
- W2766194804 title "Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells" @default.
- W2766194804 cites W1536149315 @default.
- W2766194804 cites W1964611790 @default.
- W2766194804 cites W1970326574 @default.
- W2766194804 cites W1991352044 @default.
- W2766194804 cites W2006910114 @default.
- W2766194804 cites W2014770610 @default.
- W2766194804 cites W2014855149 @default.
- W2766194804 cites W2038529547 @default.
- W2766194804 cites W2047487859 @default.
- W2766194804 cites W2049588822 @default.
- W2766194804 cites W2049970571 @default.
- W2766194804 cites W2050190834 @default.
- W2766194804 cites W2062306267 @default.
- W2766194804 cites W2062656956 @default.
- W2766194804 cites W2075253136 @default.
- W2766194804 cites W2078293038 @default.
- W2766194804 cites W2118057169 @default.
- W2766194804 cites W2136243485 @default.
- W2766194804 cites W2138095156 @default.
- W2766194804 cites W2170108604 @default.
- W2766194804 cites W2550728870 @default.
- W2766194804 cites W2589279864 @default.
- W2766194804 cites W2611604673 @default.
- W2766194804 cites W4211011102 @default.
- W2766194804 doi "https://doi.org/10.1080/15376516.2017.1395501" @default.
- W2766194804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29057713" @default.
- W2766194804 hasPublicationYear "2017" @default.
- W2766194804 type Work @default.
- W2766194804 sameAs 2766194804 @default.
- W2766194804 citedByCount "39" @default.
- W2766194804 countsByYear W27661948042018 @default.
- W2766194804 countsByYear W27661948042019 @default.
- W2766194804 countsByYear W27661948042020 @default.
- W2766194804 countsByYear W27661948042021 @default.
- W2766194804 countsByYear W27661948042022 @default.
- W2766194804 countsByYear W27661948042023 @default.
- W2766194804 crossrefType "journal-article" @default.
- W2766194804 hasAuthorship W2766194804A5006350016 @default.
- W2766194804 hasAuthorship W2766194804A5019423761 @default.
- W2766194804 hasAuthorship W2766194804A5038253965 @default.
- W2766194804 hasAuthorship W2766194804A5054690504 @default.
- W2766194804 hasConcept C104488531 @default.
- W2766194804 hasConcept C109541995 @default.
- W2766194804 hasConcept C121608353 @default.
- W2766194804 hasConcept C126322002 @default.
- W2766194804 hasConcept C134018914 @default.
- W2766194804 hasConcept C185592680 @default.
- W2766194804 hasConcept C202751555 @default.
- W2766194804 hasConcept C2777140777 @default.
- W2766194804 hasConcept C2777164284 @default.
- W2766194804 hasConcept C2777366897 @default.
- W2766194804 hasConcept C2994423619 @default.
- W2766194804 hasConcept C31903555 @default.
- W2766194804 hasConcept C530470458 @default.
- W2766194804 hasConcept C54355233 @default.
- W2766194804 hasConcept C55493867 @default.
- W2766194804 hasConcept C62112901 @default.
- W2766194804 hasConcept C71924100 @default.
- W2766194804 hasConcept C84606932 @default.
- W2766194804 hasConcept C84699730 @default.
- W2766194804 hasConcept C86803240 @default.
- W2766194804 hasConcept C96232424 @default.
- W2766194804 hasConcept C98274493 @default.
- W2766194804 hasConceptScore W2766194804C104488531 @default.
- W2766194804 hasConceptScore W2766194804C109541995 @default.
- W2766194804 hasConceptScore W2766194804C121608353 @default.
- W2766194804 hasConceptScore W2766194804C126322002 @default.
- W2766194804 hasConceptScore W2766194804C134018914 @default.
- W2766194804 hasConceptScore W2766194804C185592680 @default.
- W2766194804 hasConceptScore W2766194804C202751555 @default.
- W2766194804 hasConceptScore W2766194804C2777140777 @default.
- W2766194804 hasConceptScore W2766194804C2777164284 @default.
- W2766194804 hasConceptScore W2766194804C2777366897 @default.
- W2766194804 hasConceptScore W2766194804C2994423619 @default.
- W2766194804 hasConceptScore W2766194804C31903555 @default.
- W2766194804 hasConceptScore W2766194804C530470458 @default.
- W2766194804 hasConceptScore W2766194804C54355233 @default.
- W2766194804 hasConceptScore W2766194804C55493867 @default.
- W2766194804 hasConceptScore W2766194804C62112901 @default.
- W2766194804 hasConceptScore W2766194804C71924100 @default.
- W2766194804 hasConceptScore W2766194804C84606932 @default.
- W2766194804 hasConceptScore W2766194804C84699730 @default.
- W2766194804 hasConceptScore W2766194804C86803240 @default.
- W2766194804 hasConceptScore W2766194804C96232424 @default.
- W2766194804 hasConceptScore W2766194804C98274493 @default.
- W2766194804 hasFunder F4320321108 @default.
- W2766194804 hasIssue "4" @default.
- W2766194804 hasLocation W27661948041 @default.
- W2766194804 hasLocation W27661948042 @default.