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• W2766202320 abstract "There is increased interest in lifestyle and dementia. A major challenge in identifying lifestyle determinants of dementia is precise exposure measurement. One strategy for reducing measurement error is repeat assessment. Here, multi-trajectory analysis was used to integrate micronutrient level dietary data in relation to cognitive decline. We assess the impact of dietary B vitamins on cognitive decline in a middle aged general population sample to investigate the utility of the multi-trajectory approach to lifestyle and dementia risk. Dietary and cognitive data from UK Biobank were used to characterise dietary B vitamins (B6, B9, B12) and cognitive change. Nutrient data from 24 hour dietary recall on 4 occasions across 16 months were used to characterise B vitamin intake. Two-choice reaction time test administered on two occasions over 4 years was used to assess cognitive change. Adopting multi-trajectory analysis we identified B vitamin intake groups. Paired t-tests assessed cognitive change in terms of mean reaction time. Multiple-trajectory analysis identified two B vitamin intake groups as providing the best fit to the data: a lower vitamins intake group (n=1,910, Mean age=57.19 years, SD=7.37, range 40–70, % women 54), and a higher vitamins intake group (n=1,065, Mean age=58.01 years, SD=7.27, range 40–70, % women 46). No trend across measurement occasions was detected and the data were interpreted to represent usual intake levels. Paired sample t-tests showed that group-based reaction time scores significantly increased from baseline to re-assessment only in the lower intake group (p<0.001), while they remained stable in the higher intake group (p=0.264). These findings indicate a protective effect of higher B vitamin intake. Multi-trajectory analysis has been used to interpret repeated measurement lifestyle data; here, identifying groups representing usual exposure rather than change in exposure over time. In a general population sample, it was found that a higher usual dietary B vitamins intake is associated with a slower decline in mean reaction time over 4 years. Although further (multivariable) analysis is required to provide evidence of causality, multi-trajectory analysis is a useful tool for empirically characterising lifestyle, enabling more detailed investigation of the impact of lifestyle on dementia related outcomes. Multi-trajectories groups of vitamins B6, B9 and B12 daily intake (n=2,975). Bayesian Information Criteria (BIC)= -126067.02 (n=35,700 observations), BIC= -126048.38 (n=2,975 persons), Akaike Information Criteria (AIC)=-126003.40, L=-125988.40. Reaction time mean scores at baseline (Time 1) and re-assessment (Time 2) by multi-trajectories groups of folate, vitamins B6, B9 and B12 daily intake (n=2,975)." @default.
• W2766202320 created "2017-11-10" @default.
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• W2766202320 date "2017-07-01" @default.
• W2766202320 modified "2023-09-27" @default.
• W2766202320 title "[P4-365]: USING MULTI-TRAJECTORY ANALYSIS TO INVESTIGATE DIET AND COGNITIVE CHANGE: AN MRC DEMENTIAS PLATFORM U.K. (DPUK) SUPPORTED STUDY" @default.
• W2766202320 doi "https://doi.org/10.1016/j.jalz.2017.06.2236" @default.
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