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• W2766202507 abstract "Background: The European Society of Cardiology recommends a 0/1-hour algorithm for rapid rule-out and rule-in of non–ST-segment elevation myocardial infarction using high-sensitivity cardiac troponin (hs-cTn) concentrations irrespective of renal function. Because patients with renal dysfunction (RD) frequently present with increased hs-cTn concentrations even in the absence of non–ST-segment elevation myocardial infarction, concern has been raised regarding the performance of the 0/1-hour algorithm in RD. Methods: In a prospective multicenter diagnostic study enrolling unselected patients presenting with suspected non–ST-segment elevation myocardial infarction to the emergency department, we assessed the diagnostic performance of the European Society of Cardiology 0/1-hour algorithm using hs-cTnT and hs-cTnI in patients with RD, defined as an estimated glomerular filtration rate <60 mL/min/1.73 m 2 , and compared it to patients with normal renal function. The final diagnosis was centrally adjudicated by 2 independent cardiologists using all available information, including cardiac imaging. Safety was quantified as sensitivity in the rule-out zone, accuracy as the specificity in the rule-in zone, and efficacy as the proportion of the overall cohort assigned to either rule-out or rule-in based on the 0- and 1-hour sample. Results: Among 3254 patients, RD was present in 487 patients (15%). The prevalence of non–ST-segment elevation myocardial infarction was substantially higher in patients with RD compared with patients with normal renal function (31% versus 13%, P <0.001). Using hs-cTnT, patients with RD had comparable sensitivity of rule-out (100.0% [95% confidence interval {CI}, 97.6–100.0] versus 99.2% [95% CI, 97.6–99.8]; P =0.559), lower specificity of rule-in (88.7% [95% CI, 84.8–91.9] versus 96.5% [95% CI, 95.7–97.2]; P <0.001), and lower overall efficacy (51% versus 81%, P <0.001), mainly driven by a much lower percentage of patients eligible for rule-out (18% versus 68%, P <0.001) compared with patients with normal renal function. Using hs-cTnI, patients with RD had comparable sensitivity of rule-out (98.6% [95% CI, 95.0–99.8] versus 98.5% [95% CI, 96.5–99.5]; P =1.0), lower specificity of rule-in (84.4% [95% CI, 79.9–88.3] versus 91.7% [95% CI, 90.5–92.9]; P <0.001), and lower overall efficacy (54% versus 76%, P <0.001; proportion ruled out, 18% versus 58%, P <0.001) compared with patients with normal renal function. Conclusions: In patients with RD, the safety of the European Society of Cardiology 0/1-hour algorithm is high, but specificity of rule-in and overall efficacy are decreased. Modifications of the rule-in and rule-out thresholds did not improve the safety or overall efficacy of the 0/1-hour algorithm. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT00470587." @default.
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• W2766202507 date "2018-01-30" @default.
• W2766202507 modified "2023-10-17" @default.
• W2766202507 title "0/1-Hour Triage Algorithm for Myocardial Infarction in Patients With Renal Dysfunction" @default.
• W2766202507 cites W1525677699 @default.
• W2766202507 cites W1582447064 @default.
• W2766202507 cites W1963611077 @default.
• W2766202507 cites W1968376801 @default.
• W2766202507 cites W1971085201 @default.
• W2766202507 cites W1979675624 @default.
• W2766202507 cites W1990725108 @default.
• W2766202507 cites W2020715592 @default.
• W2766202507 cites W2025149959 @default.
• W2766202507 cites W2036022555 @default.
• W2766202507 cites W2051697763 @default.
• W2766202507 cites W2064423693 @default.
• W2766202507 cites W2072161086 @default.
• W2766202507 cites W2082069148 @default.
• W2766202507 cites W2085043887 @default.
• W2766202507 cites W2089564558 @default.
• W2766202507 cites W2098002403 @default.
• W2766202507 cites W2098105324 @default.
• W2766202507 cites W2101955369 @default.
• W2766202507 cites W2105397247 @default.
• W2766202507 cites W2107955926 @default.
• W2766202507 cites W2126830306 @default.
• W2766202507 cites W2133275623 @default.
• W2766202507 cites W2134075081 @default.
• W2766202507 cites W2139243268 @default.
• W2766202507 cites W2143448016 @default.
• W2766202507 cites W2145632027 @default.
• W2766202507 cites W2155965977 @default.
• W2766202507 cites W2157825442 @default.
• W2766202507 cites W2160843187 @default.
• W2766202507 cites W2163503047 @default.
• W2766202507 cites W2165244071 @default.
• W2766202507 cites W2167000122 @default.
• W2766202507 cites W2188214922 @default.
• W2766202507 cites W2211369246 @default.
• W2766202507 cites W2236732454 @default.
• W2766202507 cites W2312246162 @default.
• W2766202507 cites W2333911809 @default.
• W2766202507 cites W2409181092 @default.
• W2766202507 cites W2419668996 @default.
• W2766202507 cites W2422859682 @default.
• W2766202507 cites W2466383270 @default.
• W2766202507 cites W2538671047 @default.
• W2766202507 cites W2547382430 @default.
• W2766202507 cites W2587020466 @default.
• W2766202507 cites W2607031541 @default.
• W2766202507 cites W2749133321 @default.
• W2766202507 cites W2755421453 @default.
• W2766202507 cites W3183915260 @default.
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• W2766202507 doi "https://doi.org/10.1161/circulationaha.117.028901" @default.
• W2766202507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5794234" @default.
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• W2766202507 hasPublicationYear "2018" @default.
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