FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766235053> ?p ?o ?g. }

• W2766235053 abstract "Abstract Attachment sites of tendons to bones, called entheses, are essential for proper musculoskeletal function. They are formed embryonically by Sox9 + progenitors and undergo a developmental process that continues into the postnatal period and involves Gli1 lineage cells. During bone elongation, some entheses maintain their relative positions by actively migrating along the bone shaft, while others, located at the bone’s extremities, remain stationary. Despite their importance, we lack information on the developmental transition from embryonic to mature enthesis and on the relation between Sox9 + progenitors and Gli1 lineage cells. Here, by performing a series of lineage tracing experiments, we identify the onset of Gli1 lineage contribution to different entheses during embryogenesis. We show that Gli1 expression is regulated by SHH signaling during embryonic development, whereas postnatally it is maintained by IHH signaling. Interestingly, we found that unlike in stationary entheses, where Sox9 + cells differentiate into the Gli1 lineage, in migrating entheses the Sox9 lineage is replaced by Gli1 lineage and do not contribute to the mature enthesis. Moreover, we show that these Gli1+ progenitors are pre-specified embryonically to form the different cellular domains of the mature enthesis. Overall, these findings demonstrate a developmental strategy whereby one progenitor population establishes a simple, embryonic tissue, whereas another population is responsible for its maturation into a complex structure during its migration. Moreover, they suggest that different cell populations may be considered for cell-based therapy of enthesis injuries." @default.
• W2766235053 created "2017-11-10" @default.
• W2766235053 creator A5010277376 @default.
• W2766235053 creator A5014018022 @default.
• W2766235053 creator A5021791598 @default.
• W2766235053 creator A5040722433 @default.
• W2766235053 creator A5055830393 @default.
• W2766235053 creator A5057786365 @default.
• W2766235053 creator A5069634585 @default.
• W2766235053 creator A5081367646 @default.
• W2766235053 date "2017-10-29" @default.
• W2766235053 modified "2023-09-27" @default.
• W2766235053 title "Development of migrating entheses involves replacement of progenitor populations" @default.
• W2766235053 cites W1486716069 @default.
• W2766235053 cites W1544823490 @default.
• W2766235053 cites W1865339308 @default.
• W2766235053 cites W1970594545 @default.
• W2766235053 cites W1990786422 @default.
• W2766235053 cites W1995499476 @default.
• W2766235053 cites W2003386225 @default.
• W2766235053 cites W2016583814 @default.
• W2766235053 cites W2016633925 @default.
• W2766235053 cites W2017922660 @default.
• W2766235053 cites W2042932723 @default.
• W2766235053 cites W2050108052 @default.
• W2766235053 cites W2056123267 @default.
• W2766235053 cites W2074056466 @default.
• W2766235053 cites W2091533843 @default.
• W2766235053 cites W2092370688 @default.
• W2766235053 cites W2100039503 @default.
• W2766235053 cites W2104135721 @default.
• W2766235053 cites W2121276445 @default.
• W2766235053 cites W2133650431 @default.
• W2766235053 cites W2135466817 @default.
• W2766235053 cites W2156315605 @default.
• W2766235053 cites W2160709087 @default.
• W2766235053 cites W2161282017 @default.
• W2766235053 cites W2168901267 @default.
• W2766235053 cites W2336971731 @default.
• W2766235053 cites W2409820086 @default.
• W2766235053 cites W2591198681 @default.
• W2766235053 cites W763920608 @default.
• W2766235053 doi "https://doi.org/10.1101/210799" @default.
• W2766235053 hasPublicationYear "2017" @default.
• W2766235053 type Work @default.
• W2766235053 sameAs 2766235053 @default.
• W2766235053 citedByCount "1" @default.
• W2766235053 countsByYear W27662350532021 @default.
• W2766235053 crossrefType "posted-content" @default.
• W2766235053 hasAuthorship W2766235053A5010277376 @default.
• W2766235053 hasAuthorship W2766235053A5014018022 @default.
• W2766235053 hasAuthorship W2766235053A5021791598 @default.
• W2766235053 hasAuthorship W2766235053A5040722433 @default.
• W2766235053 hasAuthorship W2766235053A5055830393 @default.
• W2766235053 hasAuthorship W2766235053A5057786365 @default.
• W2766235053 hasAuthorship W2766235053A5069634585 @default.
• W2766235053 hasAuthorship W2766235053A5081367646 @default.
• W2766235053 hasBestOaLocation W27662350531 @default.
• W2766235053 hasConcept C104317684 @default.
• W2766235053 hasConcept C105702510 @default.
• W2766235053 hasConcept C145103041 @default.
• W2766235053 hasConcept C15729860 @default.
• W2766235053 hasConcept C174286582 @default.
• W2766235053 hasConcept C201750760 @default.
• W2766235053 hasConcept C2778486617 @default.
• W2766235053 hasConcept C2780105995 @default.
• W2766235053 hasConcept C28328180 @default.
• W2766235053 hasConcept C2908647359 @default.
• W2766235053 hasConcept C54355233 @default.
• W2766235053 hasConcept C71924100 @default.
• W2766235053 hasConcept C86339819 @default.
• W2766235053 hasConcept C86803240 @default.
• W2766235053 hasConcept C95444343 @default.
• W2766235053 hasConcept C99454951 @default.
• W2766235053 hasConceptScore W2766235053C104317684 @default.
• W2766235053 hasConceptScore W2766235053C105702510 @default.
• W2766235053 hasConceptScore W2766235053C145103041 @default.
• W2766235053 hasConceptScore W2766235053C15729860 @default.
• W2766235053 hasConceptScore W2766235053C174286582 @default.
• W2766235053 hasConceptScore W2766235053C201750760 @default.
• W2766235053 hasConceptScore W2766235053C2778486617 @default.
• W2766235053 hasConceptScore W2766235053C2780105995 @default.
• W2766235053 hasConceptScore W2766235053C28328180 @default.
• W2766235053 hasConceptScore W2766235053C2908647359 @default.
• W2766235053 hasConceptScore W2766235053C54355233 @default.
• W2766235053 hasConceptScore W2766235053C71924100 @default.
• W2766235053 hasConceptScore W2766235053C86339819 @default.
• W2766235053 hasConceptScore W2766235053C86803240 @default.
• W2766235053 hasConceptScore W2766235053C95444343 @default.
• W2766235053 hasConceptScore W2766235053C99454951 @default.
• W2766235053 hasLocation W27662350531 @default.
• W2766235053 hasOpenAccess W2766235053 @default.
• W2766235053 hasPrimaryLocation W27662350531 @default.
• W2766235053 hasRelatedWork W1979426829 @default.
• W2766235053 hasRelatedWork W1990110654 @default.
• W2766235053 hasRelatedWork W2014625629 @default.
• W2766235053 hasRelatedWork W2016458781 @default.
• W2766235053 hasRelatedWork W2084585178 @default.
• W2766235053 hasRelatedWork W2088872648 @default.
• W2766235053 hasRelatedWork W2113890600 @default.

• next