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• W2766238630 abstract "Background: Azithromycin has modest efficacy against malaria, and previous cluster randomized trials have suggested that mass azithromycin distribution for trachoma control may play a role in malaria control. We evaluated the effect of annual versus biannual mass azithromycin distribution over a 3-year period on malaria prevalence during the peak transmission season in a region with seasonal malaria transmission in Niger. Methods: Twenty-four communities in Matameye, Niger, were randomized to annual mass azithromycin distribution (3 distributions to the entire community during the peak transmission season) or biannual-targeted azithromycin distribution (6 distributions to children <12 years of age, including 3 in the peak transmission season and 3 in the low transmission season). Malaria indices were evaluated at 36 months during the high transmission season. Results: Parasitemia prevalence was 42.6% (95% confidence interval: 31.7%–53.6%) in the biannual distribution arm compared with 50.6% (95% confidence interval: 40.3%–60.8%) in the annual distribution arm (P = 0.29). There was no difference in parasite density or hemoglobin concentration in the 2 treatment arms. Conclusions: Additional rounds of mass azithromycin distribution during low transmission may not have a significant impact on malaria parasitemia measured during the peak transmission season." @default.
• W2766238630 created "2017-11-10" @default.
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• W2766238630 date "2018-06-01" @default.
• W2766238630 modified "2023-09-24" @default.
• W2766238630 title "Annual Versus Biannual Mass Azithromycin Distribution and Malaria Parasitemia During the Peak Transmission Season Among Children in Niger" @default.
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• W2766238630 doi "https://doi.org/10.1097/inf.0000000000001813" @default.
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