Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766249538> ?p ?o ?g. }
- W2766249538 endingPage "8" @default.
- W2766249538 startingPage "1" @default.
- W2766249538 abstract "The epidermal growth factor receptor (EGFR) is a member of the ErbB family of membrane tyrosine-kinase receptors. Studies exploring the prognostic role of EGFR-overexpression in early breast cancer have shown variable results, and the true prognostic value of EGFR is unknown.A systematic review of identified publications exploring the association between EGFR-overexpression (as defined from different techniques and cut-offs) and outcomes [disease-free (DFS) and, overall survival (OS)] in women with early breast cancer. The hazard ratios (HR) for DFS and OS were weighted and pooled in a meta-analysis using generic inverse variance and random effects modeling.Fifty-three studies comprising 21,418 women were included. EGFR-overexpression was found in 27% of the patients. Primary analysis included studies reporting HRs from multivariable analyses (10 studies including 4857 patients with HRs for OS and 17 studies comprising 8747 patients with HRs for DFS), EGFR-overexpression was associated with worse OS (HR 1.98, 95% CI: 1.59-2.47, p < .001) and DFS (HR 1.59, 95% CI 1.30-1.95, p < .001). The influence of EGFR overexpression on DFS was greater in women with triple negative tumors compared to women with non-triple negative tumors (HR 2.35 versus HR 1.45, respectively; p = .01). Analysis looking at odd ratios for both 5-year and 10-year for DFS and OS showed similar results.EGFR-overexpression appears to be associated with reduced OS and DFS in women with early breast cancer. Patients with triple negative and EGFR-overexpression have poorer OS and DFS than those with triple negative tumors and normal EGFR expression." @default.
- W2766249538 created "2017-11-10" @default.
- W2766249538 creator A5006624845 @default.
- W2766249538 creator A5006793566 @default.
- W2766249538 creator A5013926448 @default.
- W2766249538 creator A5021202830 @default.
- W2766249538 creator A5022163984 @default.
- W2766249538 creator A5029892704 @default.
- W2766249538 creator A5041589223 @default.
- W2766249538 creator A5048283327 @default.
- W2766249538 creator A5058444324 @default.
- W2766249538 creator A5063846121 @default.
- W2766249538 creator A5064078092 @default.
- W2766249538 creator A5074810713 @default.
- W2766249538 date "2018-01-01" @default.
- W2766249538 modified "2023-10-10" @default.
- W2766249538 title "Epidermal growth factor receptor overexpression and outcomes in early breast cancer: A systematic review and a meta-analysis" @default.
- W2766249538 cites W164886646 @default.
- W2766249538 cites W1919801416 @default.
- W2766249538 cites W1963739693 @default.
- W2766249538 cites W1964072495 @default.
- W2766249538 cites W1965302287 @default.
- W2766249538 cites W1966788277 @default.
- W2766249538 cites W1966822949 @default.
- W2766249538 cites W1969786962 @default.
- W2766249538 cites W1972550585 @default.
- W2766249538 cites W1979443682 @default.
- W2766249538 cites W1985620074 @default.
- W2766249538 cites W1986253570 @default.
- W2766249538 cites W1986373442 @default.
- W2766249538 cites W1986926262 @default.
- W2766249538 cites W1988055795 @default.
- W2766249538 cites W1989095274 @default.
- W2766249538 cites W1989487223 @default.
- W2766249538 cites W1989663680 @default.
- W2766249538 cites W1992581630 @default.
- W2766249538 cites W2000042618 @default.
- W2766249538 cites W2001042360 @default.
- W2766249538 cites W2006122819 @default.
- W2766249538 cites W2012377679 @default.
- W2766249538 cites W2013724343 @default.
- W2766249538 cites W2014115970 @default.
- W2766249538 cites W2016498201 @default.
- W2766249538 cites W2018332982 @default.
- W2766249538 cites W2020494463 @default.
- W2766249538 cites W2021440987 @default.
- W2766249538 cites W2026175788 @default.
- W2766249538 cites W2029548655 @default.
- W2766249538 cites W2031981401 @default.
- W2766249538 cites W2033584179 @default.
- W2766249538 cites W2034722306 @default.
- W2766249538 cites W2035810660 @default.
- W2766249538 cites W2036380800 @default.
- W2766249538 cites W2039633811 @default.
- W2766249538 cites W2054402345 @default.
- W2766249538 cites W2057592907 @default.
- W2766249538 cites W2060328904 @default.
- W2766249538 cites W2060366657 @default.
- W2766249538 cites W2061154926 @default.
- W2766249538 cites W2062819976 @default.
- W2766249538 cites W2065097865 @default.
- W2766249538 cites W2070480410 @default.
- W2766249538 cites W2080063912 @default.
- W2766249538 cites W2080138326 @default.
- W2766249538 cites W2081069364 @default.
- W2766249538 cites W2083527129 @default.
- W2766249538 cites W2084791564 @default.
- W2766249538 cites W2085880972 @default.
- W2766249538 cites W2088656245 @default.
- W2766249538 cites W2098775844 @default.
- W2766249538 cites W2100263631 @default.
- W2766249538 cites W2102379101 @default.
- W2766249538 cites W2104024752 @default.
- W2766249538 cites W2107631501 @default.
- W2766249538 cites W2123206362 @default.
- W2766249538 cites W2136034662 @default.
- W2766249538 cites W2136483162 @default.
- W2766249538 cites W2139517025 @default.
- W2766249538 cites W2148320836 @default.
- W2766249538 cites W2150132200 @default.
- W2766249538 cites W2151570079 @default.
- W2766249538 cites W2152276633 @default.
- W2766249538 cites W2153933760 @default.
- W2766249538 cites W2158077354 @default.
- W2766249538 cites W2158961508 @default.
- W2766249538 cites W2078980585 @default.
- W2766249538 doi "https://doi.org/10.1016/j.ctrv.2017.10.008" @default.
- W2766249538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29126017" @default.
- W2766249538 hasPublicationYear "2018" @default.
- W2766249538 type Work @default.
- W2766249538 sameAs 2766249538 @default.
- W2766249538 citedByCount "64" @default.
- W2766249538 countsByYear W27662495382018 @default.
- W2766249538 countsByYear W27662495382019 @default.
- W2766249538 countsByYear W27662495382020 @default.
- W2766249538 countsByYear W27662495382021 @default.
- W2766249538 countsByYear W27662495382022 @default.
- W2766249538 countsByYear W27662495382023 @default.