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- W2766252413 abstract "Molecular nanodevices are computational assemblers that switch defined states upon external stimulation. However, interfacing artificial nanodevices with natural molecular machineries in living cells remains a great challenge. Here, we delineate a generic method for programming assembly of enzyme-initiated DNAzyme nanodevices (DzNanos). Two programs including split assembly of two partzymes and toehold exchange displacement assembly of one intact DNAzyme initiated by telomerase are computed. The intact one obtains higher assembly yield and catalytic performance ascribed to proper conformation folding and active misplaced assembly. By employing MnO2 nanosheets as both DNA carriers and source of Mn2+ as DNAzyme cofactor, we find that this DzNano is well assembled via a series of conformational states in living cells and operates autonomously with sustained cleavage activity. Other enzymes can also induce corresponding DzNano assembly with defined programming modules. These DzNanos not only can monitor enzyme catalysis in situ but also will enable the implementation of cellular stages, behaviors, and pathways for basic science, diagnostic, and therapeutic applications as genetic circuits." @default.
- W2766252413 created "2017-11-10" @default.
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- W2766252413 date "2017-10-24" @default.
- W2766252413 modified "2023-10-13" @default.
- W2766252413 title "Programming Enzyme-Initiated Autonomous DNAzyme Nanodevices in Living Cells" @default.
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- W2766252413 doi "https://doi.org/10.1021/acsnano.7b06728" @default.
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