FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766283114> ?p ?o ?g. }

• W2766283114 endingPage "9532" @default.
• W2766283114 startingPage "9528" @default.
• W2766283114 abstract "The present study aimed to investigate the effect of dihydroartemisinin on the proliferation of chemotherapy‑resistant C6 rat glioma cells. The results revealed that incubation of C6 glioma cells with a range of dihydroartemisinin concentrations for 48 h led to a significant (P<0.02) reduction in the cell number. There was a ‑0.8-fold reduction in the cell count following treatment with 20 µM dihydroartemisinin when compared with the control cultures. Analysis of DNA synthesis using bromodeoxyuridine (BrdU) staining demonstrated a reduction in the BrdU‑labeling index (LI) following treatment with 20 µM dihydroartemisinin. There was a 6‑fold reduction in the BrdU‑LI compared with the control cultures. Incubation of the C6 glioma cells with dihydroartemisinin led to a concentration dependent reduction in the level of cyclic adenosine 3',5'‑monophosphate following 48 h. The percentage of apoptotic cells in the cultures incubated with 20 µM dihydroartemisinin was 54.78% compared with 2.57% in the control cultures. Incubation of the C6 glioma cells with dihydroartemisinin for 48 h led to a reduction in the percentage of cells in G2/M phase with an increase in G0/G1 phase. The control cells exhibited spindle‑shaped morphology and were actively undergoing mitosis following 48 h of culture. The morphological characteristics of the cells treated with dihydroartemisinin were demonstrated to be round with small surface projections. Therefore, treatment of glioma cells with dihydroartemisinin exhibited an antitumor effect by the induction of apoptosis. Therefore, dihydroartemisinin should be evaluated further in the animal models for the treatment of glioma." @default.
• W2766283114 created "2017-11-10" @default.
• W2766283114 creator A5017635214 @default.
• W2766283114 creator A5033729673 @default.
• W2766283114 creator A5042186972 @default.
• W2766283114 creator A5045796412 @default.
• W2766283114 creator A5067847276 @default.
• W2766283114 creator A5074588368 @default.
• W2766283114 creator A5081393364 @default.
• W2766283114 date "2017-10-19" @default.
• W2766283114 modified "2023-10-16" @default.
• W2766283114 title "Dihydroartemisinin treatment exhibits antitumor effects in glioma cells through induction of apoptosis" @default.
• W2766283114 cites W179710673 @default.
• W2766283114 cites W1964617786 @default.
• W2766283114 cites W1970510435 @default.
• W2766283114 cites W1979842763 @default.
• W2766283114 cites W1986974715 @default.
• W2766283114 cites W2001660159 @default.
• W2766283114 cites W2010459983 @default.
• W2766283114 cites W2012610188 @default.
• W2766283114 cites W2014387796 @default.
• W2766283114 cites W2014740417 @default.
• W2766283114 cites W2024217069 @default.
• W2766283114 cites W2024770192 @default.
• W2766283114 cites W2047067305 @default.
• W2766283114 cites W2077767341 @default.
• W2766283114 cites W2084533871 @default.
• W2766283114 cites W2107232024 @default.
• W2766283114 cites W2114998237 @default.
• W2766283114 cites W2131661896 @default.
• W2766283114 cites W2154357207 @default.
• W2766283114 doi "https://doi.org/10.3892/mmr.2017.7832" @default.
• W2766283114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29152657" @default.
• W2766283114 hasPublicationYear "2017" @default.
• W2766283114 type Work @default.
• W2766283114 sameAs 2766283114 @default.
• W2766283114 citedByCount "13" @default.
• W2766283114 countsByYear W27662831142019 @default.
• W2766283114 countsByYear W27662831142020 @default.
• W2766283114 countsByYear W27662831142021 @default.
• W2766283114 countsByYear W27662831142022 @default.
• W2766283114 countsByYear W27662831142023 @default.
• W2766283114 crossrefType "journal-article" @default.
• W2766283114 hasAuthorship W2766283114A5017635214 @default.
• W2766283114 hasAuthorship W2766283114A5033729673 @default.
• W2766283114 hasAuthorship W2766283114A5042186972 @default.
• W2766283114 hasAuthorship W2766283114A5045796412 @default.
• W2766283114 hasAuthorship W2766283114A5067847276 @default.
• W2766283114 hasAuthorship W2766283114A5074588368 @default.
• W2766283114 hasAuthorship W2766283114A5081393364 @default.
• W2766283114 hasBestOaLocation W27662831141 @default.
• W2766283114 hasConcept C153911025 @default.
• W2766283114 hasConcept C190283241 @default.
• W2766283114 hasConcept C203014093 @default.
• W2766283114 hasConcept C2776120307 @default.
• W2766283114 hasConcept C2778048844 @default.
• W2766283114 hasConcept C2778227246 @default.
• W2766283114 hasConcept C2778260397 @default.
• W2766283114 hasConcept C2778371730 @default.
• W2766283114 hasConcept C2781160685 @default.
• W2766283114 hasConcept C29537977 @default.
• W2766283114 hasConcept C502942594 @default.
• W2766283114 hasConcept C55493867 @default.
• W2766283114 hasConcept C62112901 @default.
• W2766283114 hasConcept C86803240 @default.
• W2766283114 hasConcept C98274493 @default.
• W2766283114 hasConceptScore W2766283114C153911025 @default.
• W2766283114 hasConceptScore W2766283114C190283241 @default.
• W2766283114 hasConceptScore W2766283114C203014093 @default.
• W2766283114 hasConceptScore W2766283114C2776120307 @default.
• W2766283114 hasConceptScore W2766283114C2778048844 @default.
• W2766283114 hasConceptScore W2766283114C2778227246 @default.
• W2766283114 hasConceptScore W2766283114C2778260397 @default.
• W2766283114 hasConceptScore W2766283114C2778371730 @default.
• W2766283114 hasConceptScore W2766283114C2781160685 @default.
• W2766283114 hasConceptScore W2766283114C29537977 @default.
• W2766283114 hasConceptScore W2766283114C502942594 @default.
• W2766283114 hasConceptScore W2766283114C55493867 @default.
• W2766283114 hasConceptScore W2766283114C62112901 @default.
• W2766283114 hasConceptScore W2766283114C86803240 @default.
• W2766283114 hasConceptScore W2766283114C98274493 @default.
• W2766283114 hasIssue "6" @default.
• W2766283114 hasLocation W27662831141 @default.
• W2766283114 hasOpenAccess W2766283114 @default.
• W2766283114 hasPrimaryLocation W27662831141 @default.
• W2766283114 hasRelatedWork W1861078759 @default.
• W2766283114 hasRelatedWork W1972509069 @default.
• W2766283114 hasRelatedWork W2064890614 @default.
• W2766283114 hasRelatedWork W2379910594 @default.
• W2766283114 hasRelatedWork W2387704253 @default.
• W2766283114 hasRelatedWork W2515675668 @default.
• W2766283114 hasRelatedWork W2944900431 @default.
• W2766283114 hasRelatedWork W3022642502 @default.
• W2766283114 hasRelatedWork W3032526538 @default.
• W2766283114 hasRelatedWork W4309884680 @default.
• W2766283114 hasVolume "16" @default.
• W2766283114 isParatext "false" @default.
• W2766283114 isRetracted "false" @default.

• next