FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766297218> ?p ?o ?g. }

• W2766297218 abstract "Harnessing immune system to treat cancer requires simultaneous generation of tumor-specific CTLs and curtailment of tumor immunosuppressive environment. Here, we developed an immunotherapeutic regimen capable of eliminating large established mouse tumors using HMGN1, a DC-activating TLR4 agonist capable of inducing anti-tumor immunity. Intratumoral delivery of HMGN1 with low dose of Cytoxan cured mice bearing small (∅ ≈ 0.5 cm), but not large (∅ ≈ 1.0 cm) CT26 tumors. Screening for activators capable of synergizing with HMGN1 in activating DC identified R848. Intratumoral delivery of HMGN1 and R848 plus Cytoxan eradicated large established CT26 tumors. The resultant tumor-free mice were resistant to subsequent challenge with CT26, indicating the generation of CT26-specific protective immunity. This immunotherapeutic regimen caused homing of tumor-infiltrating DC to draining lymph nodes and increased infiltration of T cells into tumor tissues. Cytoxan in this regimen could be replaced by anti-CTLA4) or anti-PD-L1. Importantly, this immunotherapeutic regimen was also curative for large established mouse Renca and EG7 tumors. Thus, we have developed a curative therapeutic vaccination regimen dubbed 'TheraVac' consisting of HMGN1 and R848 plus a checkpoint inhibitor, that can, without using exogenous tumor-associated antigen(s), eliminate various large tumors and induce tumor-specific immunity." @default.
• W2766297218 created "2017-11-10" @default.
• W2766297218 creator A5042240287 @default.
• W2766297218 creator A5042752501 @default.
• W2766297218 creator A5052099990 @default.
• W2766297218 creator A5054930498 @default.
• W2766297218 creator A5059944329 @default.
• W2766297218 creator A5067389857 @default.
• W2766297218 creator A5068884752 @default.
• W2766297218 date "2017-10-27" @default.
• W2766297218 modified "2023-10-15" @default.
• W2766297218 title "Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors" @default.
• W2766297218 cites W1523365630 @default.
• W2766297218 cites W1576543020 @default.
• W2766297218 cites W1678477267 @default.
• W2766297218 cites W1823780969 @default.
• W2766297218 cites W1879131976 @default.
• W2766297218 cites W1964196894 @default.
• W2766297218 cites W1973091654 @default.
• W2766297218 cites W1974620879 @default.
• W2766297218 cites W1975367143 @default.
• W2766297218 cites W1977957999 @default.
• W2766297218 cites W1979980796 @default.
• W2766297218 cites W1981424925 @default.
• W2766297218 cites W1984484036 @default.
• W2766297218 cites W1991236592 @default.
• W2766297218 cites W1994024849 @default.
• W2766297218 cites W2009219530 @default.
• W2766297218 cites W2011513757 @default.
• W2766297218 cites W2013328070 @default.
• W2766297218 cites W2016268206 @default.
• W2766297218 cites W2039484130 @default.
• W2766297218 cites W2044311801 @default.
• W2766297218 cites W2044835625 @default.
• W2766297218 cites W2045465609 @default.
• W2766297218 cites W2045743819 @default.
• W2766297218 cites W2050805027 @default.
• W2766297218 cites W2055456476 @default.
• W2766297218 cites W2081249048 @default.
• W2766297218 cites W2081596133 @default.
• W2766297218 cites W2088086152 @default.
• W2766297218 cites W2092918797 @default.
• W2766297218 cites W2093424661 @default.
• W2766297218 cites W2102866212 @default.
• W2766297218 cites W2104732141 @default.
• W2766297218 cites W2104904748 @default.
• W2766297218 cites W2112400160 @default.
• W2766297218 cites W2112601576 @default.
• W2766297218 cites W2116086384 @default.
• W2766297218 cites W2117692326 @default.
• W2766297218 cites W2124303254 @default.
• W2766297218 cites W2128897591 @default.
• W2766297218 cites W2129751113 @default.
• W2766297218 cites W2133634704 @default.
• W2766297218 cites W2150835657 @default.
• W2766297218 cites W2153328681 @default.
• W2766297218 cites W2159423482 @default.
• W2766297218 cites W2168762880 @default.
• W2766297218 cites W2171373028 @default.
• W2766297218 cites W2209812019 @default.
• W2766297218 cites W2472278322 @default.
• W2766297218 cites W2534772180 @default.
• W2766297218 cites W570360169 @default.
• W2766297218 doi "https://doi.org/10.1038/s41598-017-14655-8" @default.
• W2766297218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5660153" @default.
• W2766297218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29079801" @default.
• W2766297218 hasPublicationYear "2017" @default.
• W2766297218 type Work @default.
• W2766297218 sameAs 2766297218 @default.
• W2766297218 citedByCount "26" @default.
• W2766297218 countsByYear W27662972182018 @default.
• W2766297218 countsByYear W27662972182019 @default.
• W2766297218 countsByYear W27662972182020 @default.
• W2766297218 countsByYear W27662972182021 @default.
• W2766297218 countsByYear W27662972182022 @default.
• W2766297218 countsByYear W27662972182023 @default.
• W2766297218 crossrefType "journal-article" @default.
• W2766297218 hasAuthorship W2766297218A5042240287 @default.
• W2766297218 hasAuthorship W2766297218A5042752501 @default.
• W2766297218 hasAuthorship W2766297218A5052099990 @default.
• W2766297218 hasAuthorship W2766297218A5054930498 @default.
• W2766297218 hasAuthorship W2766297218A5059944329 @default.
• W2766297218 hasAuthorship W2766297218A5067389857 @default.
• W2766297218 hasAuthorship W2766297218A5068884752 @default.
• W2766297218 hasBestOaLocation W27662972181 @default.
• W2766297218 hasConcept C126322002 @default.
• W2766297218 hasConcept C203014093 @default.
• W2766297218 hasConcept C2777701055 @default.
• W2766297218 hasConcept C2778378633 @default.
• W2766297218 hasConcept C2779341262 @default.
• W2766297218 hasConcept C2781413609 @default.
• W2766297218 hasConcept C502942594 @default.
• W2766297218 hasConcept C71924100 @default.
• W2766297218 hasConcept C8891405 @default.
• W2766297218 hasConceptScore W2766297218C126322002 @default.
• W2766297218 hasConceptScore W2766297218C203014093 @default.
• W2766297218 hasConceptScore W2766297218C2777701055 @default.
• W2766297218 hasConceptScore W2766297218C2778378633 @default.
• W2766297218 hasConceptScore W2766297218C2779341262 @default.
• W2766297218 hasConceptScore W2766297218C2781413609 @default.

• next