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• W2766325623 abstract "Developing an ultrasensitive and high-efficient molecular imaging probe for detection of malignant tumors is extremely needed in clinical and remains a big challenge. Here, we report a novel bispecific nanoprobe for dual-targeted T2-weighed magnetic resonance imaging (MRI) of COLO-205 colorectal cancer in vivo. First, the magnetic iron oxide nanoparticles (Fe3O4@OA) were synthesized by a thermal decomposition method. Then, PEGylation of the hydrophobic Fe3O4@OA was implemented by amphiphilic DSPE-PEG2000-COOH, producing water-soluble nanoparticles (Fe3O4@PEG). Lastly, arginine-glycine-asparticacid-tumornecrosis factor-related apoptosis-inducing ligand (RGD-TRAIL), a bispecific fusion protein, was conjugated with the nanoparticle to construct molecularly multi-targeted nanoprobe, which was defined as Fe3O4@RGD-TRAIL. This Fe3O4@RGD-TRAIL was proven to exhibit extremely high relaxation property (r2 = 534 mM−1s−1) and saturation magnetization value (Ms = 92 emu/g Fe). In vitro studies showed its dual-targeting combination capacity, favorable biocompatibility and strong ability to resist against the non-specific phagocytosis. Owing to these excellent advantages, high sensitive and efficient imaging of tumor was achieved in vivo. Therefore, this RGD-TRAIL conjugated nanoprobe could be developed as a multi-targeted contrast enhancement agent for magnetic resonance molecular imaging in detection of cancer." @default.
• W2766325623 created "2017-11-10" @default.
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• W2766325623 date "2018-01-01" @default.
• W2766325623 modified "2023-10-16" @default.
• W2766325623 title "Improving sensitivity of magnetic resonance imaging by using a dual-targeted magnetic iron oxide nanoprobe" @default.
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• W2766325623 doi "https://doi.org/10.1016/j.colsurfb.2017.10.059" @default.
• W2766325623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29100127" @default.
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