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• W2766336722 abstract "A culture- and education-fair dementia diagnostic algorithm to ascertain dementia status was developed and validated by the 10/66 DRG, with strong evidence of construct, criterion and predictive validity in Asia and Latin America. However, only one African site (Nigeria) participated in the development phase while the assessment was used subsequently in other sub-Saharan African (SSA) countries. The aim of this study is to assess the validity of its core measures in SSA populations. The 10/66 dementia diagnostic assessment and algorithm were used during surveys in Nigeria, Ghana, South Africa, Central African Republic, Congo and Tanzania. The extensive data available from those sites were analysed alongside those from other 10/66 sites to estimate the size of centre and interviewer effects on the core assessments of cognition, mental state and informant report upon which the 10/66 diagnosis relies. Patterns of intercorrelation between the core assessments, and external indicators within the nomological net were assessed to understand their construct validity. Psychometric analyses (Item Response Theory) were conducted to assess possible measurement bias (DIF) across centres and to identify potential for co-calibration with score distributions from other regions. Variation in score distributions, both among and within centres, were much greater in SSA than were observed in other 10/66 regions. Informant reports of cognitive and functional decline (CSI-D relscore), and depression symptoms (EuroD), rather than the assessment of cognition (CSI-D cogscore) were mainly affected. Informant scores were between 4.2 (2.0–8.0) and 6.7 (4.0–9.5) in Central Africa vs. 1.0 (0.0–2.0) in urban Latin America and 0.5 (0.0–1.5) in urban India, while depression scores were 5.5 (4.0–7.0) in rural Ghana vs. 1.0 (0.0–3.0) in Cuba and Puerto-Rico, and 2.0 (1.0–4.0) in Peru, Mexico and Argentina. Detailed results on measurement bias that may have occurred because of differential item functioning (DIF) across cultures will be presented. Preliminary results suggest that the challenges of cross-cultural adaptation may be greater between SSA countries and other world regions." @default.
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• W2766336722 date "2017-07-01" @default.
• W2766336722 modified "2023-09-27" @default.
• W2766336722 title "CULTURE- AND EDUCATION-FAIR 10/66 DEMENTIA DIAGNOSTIC ASSESSMENT: VALIDITY OF THE CORE MEASURES IN SUB-SAHARAN AFRICAN POPULATIONS" @default.
• W2766336722 doi "https://doi.org/10.1016/j.jalz.2017.07.109" @default.
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