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- W2766357977 abstract "Phosphorylation of the RNA polymerase II (Pol II) C-terminal domain (CTD) regulates transcription of protein-coding mRNAs and noncoding RNAs. CTD function in transcription of protein-coding RNAs has been studied extensively, but its role in plant noncoding RNA transcription remains obscure. Here, using Arabidopsis thaliana CTD PHOSPHATASE-LIKE4 knockdown lines (CPL4RNAi), we showed that CPL4 functions in genome-wide, conditional production of 3′-extensions of small nuclear RNAs (snRNAs) and biogenesis of novel transcripts from protein-coding genes downstream of the snRNAs (snRNA-downstream protein-coding genes [snR-DPGs]). Production of snR-DPGs required the Pol II snRNA promoter (PIIsnR), and CPL4RNAi plants showed increased read-through of the snRNA 3′-end processing signal, leading to continuation of transcription downstream of the snRNA gene. We also discovered an unstable, intermediate-length RNA from the SMALL SCP1-LIKE PHOSPHATASE14 locus (imRNASSP14), whose expression originated from the 5′ region of a protein-coding gene. Expression of the imRNASSP14 was driven by a PIIsnR and was conditionally 3′-extended to produce an mRNA. In the wild type, salt stress induced the snRNA-to-snR-DPG switch, which was associated with alterations of Pol II-CTD phosphorylation at the target loci. The snR-DPG transcripts occur widely in plants, suggesting that the transcriptional snRNA-to-snR-DPG switch may be a ubiquitous mechanism to regulate plant gene expression in response to environmental stresses." @default.
- W2766357977 created "2017-11-10" @default.
- W2766357977 creator A5050429695 @default.
- W2766357977 creator A5058328352 @default.
- W2766357977 creator A5059850276 @default.
- W2766357977 creator A5061513103 @default.
- W2766357977 date "2017-11-01" @default.
- W2766357977 modified "2023-10-11" @default.
- W2766357977 title "Salt Stress and CTD PHOSPHATASE-LIKE4 Mediate the Switch between Production of Small Nuclear RNAs and mRNAs" @default.
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