Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766362133> ?p ?o ?g. }
- W2766362133 abstract "Mechanical circulatory support devices, such as total artificial hearts and left ventricular assist devices, rely on external energy sources for their continuous operation. Clinically approved power supplies rely on percutaneous cables connecting an external energy source to the implanted device with the associated risk of infections. One alternative, investigated in the 70s and 80s, employs a fully implanted nuclear power source. The heat generated by the nuclear decay can be converted into electricity to power circulatory support devices. Due to the low conversion efficiencies, substantial levels of waste heat are generated and must be dissipated to avoid tissue damage, heat stroke, and death. The present work computationally evaluates the ability of the blood flow in the descending aorta to remove the locally generated waste heat for subsequent full-body distribution and dissipation, with the specific aim of investigating methods for containment of local peak temperatures within physiologically acceptable limits. To this aim, coupled fluid-solid heat transfer computational models of the blood flow in the human aorta and different heat exchanger architectures are developed. Particle tracking is used to evaluate temperature histories of cells passing through the heat exchanger region. The use of the blood flow in the descending aorta as a heat sink proves to be a viable approach for the removal of waste heat loads. With the basic heat exchanger design, blood thermal boundary layer temperatures exceed 50°C, possibly damaging blood cells and proteins. Improved designs of the heat exchanger, with the addition of fins and heat guides, allow for drastically lower blood temperatures, possibly leading to a more biocompatible implant. The ability to maintain blood temperatures at biologically compatible levels will ultimately allow for the body-wise distribution, and subsequent dissipation, of heat loads with minimum effects on the human physiology." @default.
- W2766362133 created "2017-11-10" @default.
- W2766362133 creator A5011976700 @default.
- W2766362133 creator A5027243652 @default.
- W2766362133 creator A5068618591 @default.
- W2766362133 date "2017-10-17" @default.
- W2766362133 modified "2023-09-28" @default.
- W2766362133 title "Intracorporeal Heat Distribution from Fully Implantable Energy Sources for Mechanical Circulatory Support: A Computational Proof-of-Concept Study" @default.
- W2766362133 cites W1499392909 @default.
- W2766362133 cites W1599595176 @default.
- W2766362133 cites W1726564695 @default.
- W2766362133 cites W1784105680 @default.
- W2766362133 cites W1928211086 @default.
- W2766362133 cites W1950341920 @default.
- W2766362133 cites W1966170916 @default.
- W2766362133 cites W1973446305 @default.
- W2766362133 cites W1985326488 @default.
- W2766362133 cites W1988212011 @default.
- W2766362133 cites W1997780004 @default.
- W2766362133 cites W2037375669 @default.
- W2766362133 cites W2038828978 @default.
- W2766362133 cites W2045266991 @default.
- W2766362133 cites W2060021951 @default.
- W2766362133 cites W2081136050 @default.
- W2766362133 cites W2082422448 @default.
- W2766362133 cites W2091987421 @default.
- W2766362133 cites W2108156759 @default.
- W2766362133 cites W2111812071 @default.
- W2766362133 cites W2120307542 @default.
- W2766362133 cites W2131895213 @default.
- W2766362133 cites W2133277676 @default.
- W2766362133 cites W2146132623 @default.
- W2766362133 cites W2178692484 @default.
- W2766362133 cites W2180537859 @default.
- W2766362133 cites W2183262961 @default.
- W2766362133 cites W2196906371 @default.
- W2766362133 cites W2329099082 @default.
- W2766362133 cites W2330164099 @default.
- W2766362133 cites W2341988555 @default.
- W2766362133 cites W2344592972 @default.
- W2766362133 cites W2409626348 @default.
- W2766362133 cites W2417951609 @default.
- W2766362133 cites W2439813175 @default.
- W2766362133 cites W29781625 @default.
- W2766362133 cites W4229653650 @default.
- W2766362133 cites W4239035167 @default.
- W2766362133 doi "https://doi.org/10.3389/fbioe.2017.00060" @default.
- W2766362133 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5651526" @default.
- W2766362133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29094038" @default.
- W2766362133 hasPublicationYear "2017" @default.
- W2766362133 type Work @default.
- W2766362133 sameAs 2766362133 @default.
- W2766362133 citedByCount "0" @default.
- W2766362133 crossrefType "journal-article" @default.
- W2766362133 hasAuthorship W2766362133A5011976700 @default.
- W2766362133 hasAuthorship W2766362133A5027243652 @default.
- W2766362133 hasAuthorship W2766362133A5068618591 @default.
- W2766362133 hasBestOaLocation W27663621331 @default.
- W2766362133 hasConcept C107706546 @default.
- W2766362133 hasConcept C116915560 @default.
- W2766362133 hasConcept C121332964 @default.
- W2766362133 hasConcept C127413603 @default.
- W2766362133 hasConcept C136229726 @default.
- W2766362133 hasConcept C184235594 @default.
- W2766362133 hasConcept C186937647 @default.
- W2766362133 hasConcept C192562407 @default.
- W2766362133 hasConcept C21880701 @default.
- W2766362133 hasConcept C3020116064 @default.
- W2766362133 hasConcept C39432304 @default.
- W2766362133 hasConcept C50517652 @default.
- W2766362133 hasConcept C57879066 @default.
- W2766362133 hasConcept C71924100 @default.
- W2766362133 hasConcept C78519656 @default.
- W2766362133 hasConcept C97355855 @default.
- W2766362133 hasConceptScore W2766362133C107706546 @default.
- W2766362133 hasConceptScore W2766362133C116915560 @default.
- W2766362133 hasConceptScore W2766362133C121332964 @default.
- W2766362133 hasConceptScore W2766362133C127413603 @default.
- W2766362133 hasConceptScore W2766362133C136229726 @default.
- W2766362133 hasConceptScore W2766362133C184235594 @default.
- W2766362133 hasConceptScore W2766362133C186937647 @default.
- W2766362133 hasConceptScore W2766362133C192562407 @default.
- W2766362133 hasConceptScore W2766362133C21880701 @default.
- W2766362133 hasConceptScore W2766362133C3020116064 @default.
- W2766362133 hasConceptScore W2766362133C39432304 @default.
- W2766362133 hasConceptScore W2766362133C50517652 @default.
- W2766362133 hasConceptScore W2766362133C57879066 @default.
- W2766362133 hasConceptScore W2766362133C71924100 @default.
- W2766362133 hasConceptScore W2766362133C78519656 @default.
- W2766362133 hasConceptScore W2766362133C97355855 @default.
- W2766362133 hasLocation W27663621331 @default.
- W2766362133 hasLocation W27663621332 @default.
- W2766362133 hasLocation W27663621333 @default.
- W2766362133 hasLocation W27663621334 @default.
- W2766362133 hasOpenAccess W2766362133 @default.
- W2766362133 hasPrimaryLocation W27663621331 @default.
- W2766362133 hasRelatedWork W1576043281 @default.
- W2766362133 hasRelatedWork W183761313 @default.
- W2766362133 hasRelatedWork W2044469169 @default.
- W2766362133 hasRelatedWork W2065454741 @default.