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• W2766367869 abstract "Abstract Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart Study participants to identify epigenetic signatures of kidney function. Of 19 CpG sites significantly associated ( P < 1e-07) with eGFR/CKD and replicated, five also associate with renal fibrosis in biopsies from CKD patients and show concordant DNA methylation changes in kidney cortex. Lead CpGs at PTPN6 / PHB2 , ANKRD11 , and TNRC18 map to active enhancers in kidney cortex. At PTPN6 / PHB2 cg19942083, methylation in kidney cortex associates with lower renal PTPN6 expression, higher eGFR, and less renal fibrosis. The regions containing the 243 eGFR-associated ( P < 1e-05) CpGs are significantly enriched for transcription factor binding sites of EBF1, EP300, and CEBPB ( P < 5e-6). Our findings highlight kidney function associated epigenetic variation." @default.
• W2766367869 created "2017-11-10" @default.
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• W2766367869 date "2017-11-03" @default.
• W2766367869 modified "2023-10-12" @default.
• W2766367869 title "Epigenome-wide association studies identify DNA methylation associated with kidney function" @default.
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• W2766367869 doi "https://doi.org/10.1038/s41467-017-01297-7" @default.
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