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- W2766372018 abstract "The aim of this work is to assess the performance of a prototype compact gamma camera (MediPROBE) based on a CdTe semiconductor hybrid pixel detector for coded aperture imaging. This probe can be adopted for various tasks in nuclear medicine such as preoperative sentinel lymph node localization, breast imaging with 99mTc-sestamibi and thyroid imaging with iodinated radioisotopes. The hybrid detector is an assembly of a 1mm thick CdTe semiconductor detector (sensitive area 14.08×14.08 mm2) bump-bonded to a photon-counting CMOS readout circuit of the Medipix2 series (256×256 square pixels, 55-μm pitch) or with a photon counting, energy-sensitive Timepix detector (128×128 square pixels, 110-μm pixel pitch). MediPROBE is equipped with a set of three interchangeable knife-edge pinhole collimators (hole aperture of 0.78 mm, 1 mm, or 1.9 mm) and a set of two coded aperture masks with 0.070-mm or 0.080-mm round holes. We performed measurements of field of view (FOV), system spatial resolution, and signal-difference-to-noise ratio (SDNR) by using a point-like gamma-emitting 241Am source (60 keV). The detector is operated at a single low-energy threshold of about 5 keV. At 60 keV the sensitivity is 0.0085 cps/kBq (w/0.78 mm pinhole). The system spatial resolution was 2.57 mm FWHM (w/ 0.78 mm pinhole) at a source-collimator distance of 45 mm, and 0.560 mm FWHM (w/ coded aperture 0.080 mm) at a source-collimator distance of 50 mm. We observed greater values of SDNR with the use of the coded aperture and the Timepix detector. A clinical trial is ongoing to evaluate the performance of MediPROBE for gamma-ray nuclear imaging." @default.
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- W2766372018 date "2016-10-01" @default.
- W2766372018 modified "2023-09-23" @default.
- W2766372018 title "Performance of the mediPROBE compact gamma camera for coded aperture imaging" @default.
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- W2766372018 doi "https://doi.org/10.1109/nssmic.2016.8069612" @default.
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