Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766431004> ?p ?o ?g. }
- W2766431004 endingPage "122" @default.
- W2766431004 startingPage "114" @default.
- W2766431004 abstract "Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative option for treatment of some malignant and non-malignant hematological diseases. However, post-HSCT patients are severely immunocompromised and susceptible to viral infections, which are a major cause of morbidity and mortality. Although antiviral agents are now available for most types of viral infections, they are not devoid of side effects and their efficacy is limited when there is no concomitant antiviral immune reconstitution. In recent decades, adoptive transfer of viral-specific T cells (VSTs) became an alternative treatment for viral infection after HSCT. However, two major issues are concerned in VST transfer: the risk of GVHD and antiviral efficacy. We report an exhaustive review of the published studies that focus on prophylactic and/or curative therapy by donor VST transfer for post-HSCT common viral infections. A low incidence of GVHD and a good antiviral efficacy was observed after adoptive transfer of VSTs from HSCT donor. Viral-specific T-cell transfer is a promising approach for a broad clinical application. Nevertheless, a randomized controlled study in a large cohort of patients comparing antiviral treatment alone to antiviral treatment combined with VSTs is still needed to demonstrate efficacy and safety." @default.
- W2766431004 created "2017-11-10" @default.
- W2766431004 creator A5037312078 @default.
- W2766431004 creator A5045859349 @default.
- W2766431004 creator A5051537172 @default.
- W2766431004 creator A5051712823 @default.
- W2766431004 creator A5060750035 @default.
- W2766431004 creator A5079563973 @default.
- W2766431004 creator A5082108565 @default.
- W2766431004 date "2017-10-23" @default.
- W2766431004 modified "2023-10-07" @default.
- W2766431004 title "Viral-specific T-cell transfer from HSCT donor for the treatment of viral infections or diseases after HSCT" @default.
- W2766431004 cites W1496775914 @default.
- W2766431004 cites W1554018264 @default.
- W2766431004 cites W1834144979 @default.
- W2766431004 cites W1885893763 @default.
- W2766431004 cites W1961720459 @default.
- W2766431004 cites W1965808102 @default.
- W2766431004 cites W1972442348 @default.
- W2766431004 cites W1973683879 @default.
- W2766431004 cites W1976058260 @default.
- W2766431004 cites W1976256286 @default.
- W2766431004 cites W1978110847 @default.
- W2766431004 cites W1978711879 @default.
- W2766431004 cites W1979072449 @default.
- W2766431004 cites W1983062149 @default.
- W2766431004 cites W1993732758 @default.
- W2766431004 cites W2000733814 @default.
- W2766431004 cites W2001322181 @default.
- W2766431004 cites W2007092861 @default.
- W2766431004 cites W2008957893 @default.
- W2766431004 cites W2009944606 @default.
- W2766431004 cites W2012929919 @default.
- W2766431004 cites W2014698000 @default.
- W2766431004 cites W2015899626 @default.
- W2766431004 cites W2017769703 @default.
- W2766431004 cites W2026951308 @default.
- W2766431004 cites W2029212524 @default.
- W2766431004 cites W2040400654 @default.
- W2766431004 cites W2044415798 @default.
- W2766431004 cites W2047654743 @default.
- W2766431004 cites W2053463299 @default.
- W2766431004 cites W2063128000 @default.
- W2766431004 cites W2066214953 @default.
- W2766431004 cites W2069720281 @default.
- W2766431004 cites W2073740449 @default.
- W2766431004 cites W2078126933 @default.
- W2766431004 cites W2078390252 @default.
- W2766431004 cites W2096565460 @default.
- W2766431004 cites W2119627739 @default.
- W2766431004 cites W2121779980 @default.
- W2766431004 cites W2122615595 @default.
- W2766431004 cites W2123440147 @default.
- W2766431004 cites W2135330281 @default.
- W2766431004 cites W2139450265 @default.
- W2766431004 cites W2153549003 @default.
- W2766431004 cites W2158849175 @default.
- W2766431004 cites W2161944139 @default.
- W2766431004 cites W2163275132 @default.
- W2766431004 cites W2163646709 @default.
- W2766431004 cites W2315098267 @default.
- W2766431004 cites W2328057785 @default.
- W2766431004 cites W2340809593 @default.
- W2766431004 cites W2343549959 @default.
- W2766431004 cites W2399328737 @default.
- W2766431004 cites W2465355173 @default.
- W2766431004 cites W2506616866 @default.
- W2766431004 cites W2513922839 @default.
- W2766431004 cites W2561322596 @default.
- W2766431004 cites W2571936882 @default.
- W2766431004 cites W2573546687 @default.
- W2766431004 cites W2612653841 @default.
- W2766431004 cites W2626430246 @default.
- W2766431004 doi "https://doi.org/10.1038/bmt.2017.232" @default.
- W2766431004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29058697" @default.
- W2766431004 hasPublicationYear "2017" @default.
- W2766431004 type Work @default.
- W2766431004 sameAs 2766431004 @default.
- W2766431004 citedByCount "27" @default.
- W2766431004 countsByYear W27664310042018 @default.
- W2766431004 countsByYear W27664310042019 @default.
- W2766431004 countsByYear W27664310042020 @default.
- W2766431004 countsByYear W27664310042021 @default.
- W2766431004 countsByYear W27664310042022 @default.
- W2766431004 countsByYear W27664310042023 @default.
- W2766431004 crossrefType "journal-article" @default.
- W2766431004 hasAuthorship W2766431004A5037312078 @default.
- W2766431004 hasAuthorship W2766431004A5045859349 @default.
- W2766431004 hasAuthorship W2766431004A5051537172 @default.
- W2766431004 hasAuthorship W2766431004A5051712823 @default.
- W2766431004 hasAuthorship W2766431004A5060750035 @default.
- W2766431004 hasAuthorship W2766431004A5079563973 @default.
- W2766431004 hasAuthorship W2766431004A5082108565 @default.
- W2766431004 hasBestOaLocation W27664310041 @default.
- W2766431004 hasConcept C126322002 @default.
- W2766431004 hasConcept C203014093 @default.
- W2766431004 hasConcept C2776090121 @default.
- W2766431004 hasConcept C2777408962 @default.