FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766434110> ?p ?o ?g. }

• W2766434110 abstract "ABSTRACT Breast cancer is the most frequent tumor in women and its incidence is increasing. Neoadjuvant chemotherapy has become standard of care as a complement to surgery in locally advanced or poor-prognosis early stage disease. The achievement of a complete response to neoadjuvant chemotherapy correlates with prognosis but it is not possible to predict who will obtain an excellent response. The molecular analysis of the tumor offers a unique opportunity to unveil predictive factors. In this work, gene expression profiling in 279 tumor samples from patients receiving neoadjuvant chemotherapy was performed and probabilistic graphical models were used. This approach enables addressing biological and clinical questions from a Systems Biology perspective, allowing to deal with large gene expression data and their interactions. Tumors presenting complete response to neoadjuvant chemotherapy had a higher activity of immune related functions compared to resistant tumors. Similarly, samples from complete responders presented higher expression of lymphocyte cell lineage markers, immune-activating and immune-suppressive markers, which may correlate with tumor infiltration by lymphocytes (TILs). These results suggest that the patient’s immune system plays a key role in tumor response to neoadjuvant treatment. However, future studies with larger cohorts are necessary to validate these hypotheses." @default.
• W2766434110 created "2017-11-10" @default.
• W2766434110 creator A5000204001 @default.
• W2766434110 creator A5001479108 @default.
• W2766434110 creator A5010708694 @default.
• W2766434110 creator A5023055680 @default.
• W2766434110 creator A5028827545 @default.
• W2766434110 creator A5048416170 @default.
• W2766434110 creator A5052197449 @default.
• W2766434110 creator A5053108880 @default.
• W2766434110 creator A5059984074 @default.
• W2766434110 creator A5074100416 @default.
• W2766434110 creator A5080250482 @default.
• W2766434110 creator A5081970578 @default.
• W2766434110 date "2017-10-27" @default.
• W2766434110 modified "2023-09-29" @default.
• W2766434110 title "Probabilistic Graphical Models Relate Immune Status with Response to Neoadjuvant Chemo-Therapy in Breast Cancer" @default.
• W2766434110 cites W1757407923 @default.
• W2766434110 cites W2033124645 @default.
• W2766434110 cites W2045909049 @default.
• W2766434110 cites W2097255042 @default.
• W2766434110 cites W2108458140 @default.
• W2766434110 cites W2116760308 @default.
• W2766434110 cites W2121651329 @default.
• W2766434110 cites W2132144873 @default.
• W2766434110 cites W2132619562 @default.
• W2766434110 cites W2133764807 @default.
• W2766434110 cites W2138734774 @default.
• W2766434110 cites W2154142993 @default.
• W2766434110 cites W2158794266 @default.
• W2766434110 cites W2159274850 @default.
• W2766434110 cites W2160450758 @default.
• W2766434110 cites W2164278381 @default.
• W2766434110 cites W2168064072 @default.
• W2766434110 cites W2430731787 @default.
• W2766434110 cites W2552488501 @default.
• W2766434110 cites W2747315575 @default.
• W2766434110 doi "https://doi.org/10.1101/210112" @default.
• W2766434110 hasPublicationYear "2017" @default.
• W2766434110 type Work @default.
• W2766434110 sameAs 2766434110 @default.
• W2766434110 citedByCount "0" @default.
• W2766434110 crossrefType "posted-content" @default.
• W2766434110 hasAuthorship W2766434110A5000204001 @default.
• W2766434110 hasAuthorship W2766434110A5001479108 @default.
• W2766434110 hasAuthorship W2766434110A5010708694 @default.
• W2766434110 hasAuthorship W2766434110A5023055680 @default.
• W2766434110 hasAuthorship W2766434110A5028827545 @default.
• W2766434110 hasAuthorship W2766434110A5048416170 @default.
• W2766434110 hasAuthorship W2766434110A5052197449 @default.
• W2766434110 hasAuthorship W2766434110A5053108880 @default.
• W2766434110 hasAuthorship W2766434110A5059984074 @default.
• W2766434110 hasAuthorship W2766434110A5074100416 @default.
• W2766434110 hasAuthorship W2766434110A5080250482 @default.
• W2766434110 hasAuthorship W2766434110A5081970578 @default.
• W2766434110 hasBestOaLocation W27664341101 @default.
• W2766434110 hasConcept C104317684 @default.
• W2766434110 hasConcept C121608353 @default.
• W2766434110 hasConcept C126322002 @default.
• W2766434110 hasConcept C143998085 @default.
• W2766434110 hasConcept C150194340 @default.
• W2766434110 hasConcept C18431079 @default.
• W2766434110 hasConcept C203014093 @default.
• W2766434110 hasConcept C2776694085 @default.
• W2766434110 hasConcept C2777701055 @default.
• W2766434110 hasConcept C2778292576 @default.
• W2766434110 hasConcept C2778326572 @default.
• W2766434110 hasConcept C530470458 @default.
• W2766434110 hasConcept C55493867 @default.
• W2766434110 hasConcept C71924100 @default.
• W2766434110 hasConcept C86803240 @default.
• W2766434110 hasConcept C8891405 @default.
• W2766434110 hasConceptScore W2766434110C104317684 @default.
• W2766434110 hasConceptScore W2766434110C121608353 @default.
• W2766434110 hasConceptScore W2766434110C126322002 @default.
• W2766434110 hasConceptScore W2766434110C143998085 @default.
• W2766434110 hasConceptScore W2766434110C150194340 @default.
• W2766434110 hasConceptScore W2766434110C18431079 @default.
• W2766434110 hasConceptScore W2766434110C203014093 @default.
• W2766434110 hasConceptScore W2766434110C2776694085 @default.
• W2766434110 hasConceptScore W2766434110C2777701055 @default.
• W2766434110 hasConceptScore W2766434110C2778292576 @default.
• W2766434110 hasConceptScore W2766434110C2778326572 @default.
• W2766434110 hasConceptScore W2766434110C530470458 @default.
• W2766434110 hasConceptScore W2766434110C55493867 @default.
• W2766434110 hasConceptScore W2766434110C71924100 @default.
• W2766434110 hasConceptScore W2766434110C86803240 @default.
• W2766434110 hasConceptScore W2766434110C8891405 @default.
• W2766434110 hasLocation W27664341101 @default.
• W2766434110 hasLocation W27664341102 @default.
• W2766434110 hasLocation W27664341103 @default.
• W2766434110 hasOpenAccess W2766434110 @default.
• W2766434110 hasPrimaryLocation W27664341101 @default.
• W2766434110 hasRelatedWork W1552102585 @default.
• W2766434110 hasRelatedWork W1971790974 @default.
• W2766434110 hasRelatedWork W1978440213 @default.
• W2766434110 hasRelatedWork W2002876292 @default.
• W2766434110 hasRelatedWork W2171518475 @default.
• W2766434110 hasRelatedWork W2222668738 @default.
• W2766434110 hasRelatedWork W2285498945 @default.

• next