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• W2766448145 abstract "Connexin 43 (Cx43) is the most ubiquitous connexin in various cells, and presents as hemichannels (HCs) and gap junctions (GJs) on the cell membrane. We have recently shown that Cx43 abundance was strongly reduced in fibroblasts of human gingival wounds, and blocking Cx43 function in cultured human gingival fibroblasts (GFBLs) strongly regulated the expression of wound healing-related genes. However, it is not known whether these responses involved Cx43 HCs or GJs. Here we show that Cx43 assembled into distinct GJ and HC plaques in GFBLs both in vivo and in vitro. Specific blockage of Cx43 HC function by TAT-Gap19, a Cx43 mimetic peptide, significantly upregulated the expression of several MMPs, TGF-β signaling molecules, Tenascin-C, and VEGF-A, while pro-fibrotic molecules, including several extracellular matrix proteins and myofibroblast and cell contractility-related molecules, were significantly downregulated. These changes were linked with TAT-Gap19-induced suppression of ATP signaling and activation of the ERK1/2 signaling pathway. Collectively, our data suggest that reduced Cx43 HC function could promote fast and scarless gingival wound healing. Thus, selective suppression of Cx43 HCs may provide a novel target to modulate wound healing." @default.
• W2766448145 created "2017-11-10" @default.
• W2766448145 creator A5046010058 @default.
• W2766448145 creator A5048200369 @default.
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• W2766448145 creator A5057419396 @default.
• W2766448145 creator A5066095948 @default.
• W2766448145 date "2017-10-26" @default.
• W2766448145 modified "2023-10-16" @default.
• W2766448145 title "Connexin 43 Hemichannels Regulate the Expression of Wound Healing-Associated Genes in Human Gingival Fibroblasts" @default.
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• W2766448145 doi "https://doi.org/10.1038/s41598-017-12672-1" @default.
• W2766448145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5658368" @default.
• W2766448145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29074845" @default.
• W2766448145 hasPublicationYear "2017" @default.
• W2766448145 type Work @default.
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• W2766448145 citedByCount "41" @default.

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