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• W2766459769 abstract "Ribosome assembly is an evolutionarily conserved and energy intensive process required for cellular growth, proliferation, and maintenance. In yeast, assembly of the small ribosomal subunit (SSU) requires approximately 75 assembly factors that act in coordination to form the SSU processome, a 6 MDa ribonucleoprotein complex. The SSU processome is required for processing, modifying, and folding the preribosomal RNA (rRNA) to prepare it for incorporation into the mature SSU. Although the protein composition of the SSU processome has been known for some time, the interaction network of the proteins required for its assembly has remained poorly defined. Here, we have used a semi-high-throughput yeast two-hybrid (Y2H) assay and coimmunoprecipitation validation method to produce a high-confidence interactome of SSU processome assembly factors (SPAFs), providing essential insight into SSU assembly and ribosome biogenesis. Further, we used glycerol density-gradient sedimentation to reveal the presence of protein subcomplexes that have not previously been observed. Our work not only provides essential insight into SSU assembly and ribosome biogenesis, but also serves as an important resource for future investigations into how defects in biogenesis and assembly cause congenital disorders of ribosomes known as ribosomopathies." @default.
• W2766459769 created "2017-11-10" @default.
• W2766459769 creator A5014028838 @default.
• W2766459769 creator A5029975604 @default.
• W2766459769 creator A5053877869 @default.
• W2766459769 date "2017-10-20" @default.
• W2766459769 modified "2023-10-16" @default.
• W2766459769 title "The SSU processome interactome in <i>Saccharomyces cerevisiae</i> reveals novel protein subcomplexes" @default.
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• W2766459769 doi "https://doi.org/10.1261/rna.062927.117" @default.
• W2766459769 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5733573" @default.
• W2766459769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29054886" @default.
• W2766459769 hasPublicationYear "2017" @default.
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