Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766459926> ?p ?o ?g. }
- W2766459926 endingPage "e0186954" @default.
- W2766459926 startingPage "e0186954" @default.
- W2766459926 abstract "Microsporidiosis are diseases caused by opportunistic intracellular fungi in immunosuppressed individuals, as well as in transplanted patients, the elderly and children, among others. Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and decreased T cell response, neutrophil function, humoral immunity failure, increasing the susceptibility to infections. Here, we investigated the susceptibility of streptozotocin (STZ)-induced type I diabetic and/or immunosuppressed mice to encephalitozoonosis by Encephalitozoon cuniculi. Microscopically, granulomatous hepatitis, interstitial pneumonia and pielonephritis were observed in all infected groups. STZ treatment induced an immunossupressor effect in the populations of B (B-1 and B2) and CD4+ T lymphocytes. Moreover, infection decreased CD4+ and CD8+ T lymphocytes and macrophages of DM mice. Furthermore, infection induced a significant increase of IL-6 and TNF-α cytokine serum levels in DM mice. IFN-γ, the most important cytokine for the resolution of encephalitozoonosis, increased only in infected mice. In addition to the decreased immune response, DM mice were more susceptible to encephalitozoonosis, associated with increased fungal burden, and symptoms. Additionally, cyclophosphamide immunosuppression in DM mice further increased the susceptibility to encephalitozoonosis. Thus, microsporidiosis should be considered in the differential diagnosis of comorbidities in diabetics." @default.
- W2766459926 created "2017-11-10" @default.
- W2766459926 creator A5003932443 @default.
- W2766459926 creator A5015826109 @default.
- W2766459926 creator A5017947953 @default.
- W2766459926 creator A5034589912 @default.
- W2766459926 creator A5063704677 @default.
- W2766459926 creator A5066795747 @default.
- W2766459926 creator A5087024885 @default.
- W2766459926 creator A5054166148 @default.
- W2766459926 date "2017-11-01" @default.
- W2766459926 modified "2023-09-27" @default.
- W2766459926 title "Diabetes mellitus increases the susceptibility to encephalitozoonosis in mice" @default.
- W2766459926 cites W1826447492 @default.
- W2766459926 cites W1887021539 @default.
- W2766459926 cites W1948664352 @default.
- W2766459926 cites W1979281993 @default.
- W2766459926 cites W1981980855 @default.
- W2766459926 cites W1987243736 @default.
- W2766459926 cites W1988525091 @default.
- W2766459926 cites W1993131507 @default.
- W2766459926 cites W1996365780 @default.
- W2766459926 cites W1998794592 @default.
- W2766459926 cites W2004069996 @default.
- W2766459926 cites W2006902295 @default.
- W2766459926 cites W2012922541 @default.
- W2766459926 cites W2021267418 @default.
- W2766459926 cites W2022254967 @default.
- W2766459926 cites W2024020026 @default.
- W2766459926 cites W2030764530 @default.
- W2766459926 cites W2038390887 @default.
- W2766459926 cites W2039942462 @default.
- W2766459926 cites W2041504792 @default.
- W2766459926 cites W2041696870 @default.
- W2766459926 cites W2041750809 @default.
- W2766459926 cites W2043623938 @default.
- W2766459926 cites W2049382834 @default.
- W2766459926 cites W2052897079 @default.
- W2766459926 cites W2057811513 @default.
- W2766459926 cites W2060461283 @default.
- W2766459926 cites W2076921982 @default.
- W2766459926 cites W2080101395 @default.
- W2766459926 cites W2102568434 @default.
- W2766459926 cites W2105225364 @default.
- W2766459926 cites W2105875335 @default.
- W2766459926 cites W2110959173 @default.
- W2766459926 cites W2139912792 @default.
- W2766459926 cites W2149572768 @default.
- W2766459926 cites W2149655890 @default.
- W2766459926 cites W2153807541 @default.
- W2766459926 cites W2158229692 @default.
- W2766459926 cites W2167201288 @default.
- W2766459926 cites W2231263291 @default.
- W2766459926 cites W2323376245 @default.
- W2766459926 cites W2335262903 @default.
- W2766459926 cites W2338805374 @default.
- W2766459926 cites W2412048479 @default.
- W2766459926 cites W2416512496 @default.
- W2766459926 cites W2525967235 @default.
- W2766459926 doi "https://doi.org/10.1371/journal.pone.0186954" @default.
- W2766459926 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5665527" @default.
- W2766459926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29091912" @default.
- W2766459926 hasPublicationYear "2017" @default.
- W2766459926 type Work @default.
- W2766459926 sameAs 2766459926 @default.
- W2766459926 citedByCount "8" @default.
- W2766459926 countsByYear W27664599262018 @default.
- W2766459926 countsByYear W27664599262019 @default.
- W2766459926 countsByYear W27664599262020 @default.
- W2766459926 countsByYear W27664599262022 @default.
- W2766459926 countsByYear W27664599262023 @default.
- W2766459926 crossrefType "journal-article" @default.
- W2766459926 hasAuthorship W2766459926A5003932443 @default.
- W2766459926 hasAuthorship W2766459926A5015826109 @default.
- W2766459926 hasAuthorship W2766459926A5017947953 @default.
- W2766459926 hasAuthorship W2766459926A5034589912 @default.
- W2766459926 hasAuthorship W2766459926A5054166148 @default.
- W2766459926 hasAuthorship W2766459926A5063704677 @default.
- W2766459926 hasAuthorship W2766459926A5066795747 @default.
- W2766459926 hasAuthorship W2766459926A5087024885 @default.
- W2766459926 hasBestOaLocation W27664599261 @default.
- W2766459926 hasConcept C134018914 @default.
- W2766459926 hasConcept C167672396 @default.
- W2766459926 hasConcept C174618031 @default.
- W2766459926 hasConcept C203014093 @default.
- W2766459926 hasConcept C2777965673 @default.
- W2766459926 hasConcept C2778048844 @default.
- W2766459926 hasConcept C2778690821 @default.
- W2766459926 hasConcept C2779525314 @default.
- W2766459926 hasConcept C2780252810 @default.
- W2766459926 hasConcept C2780827966 @default.
- W2766459926 hasConcept C3019824283 @default.
- W2766459926 hasConcept C555293320 @default.
- W2766459926 hasConcept C71924100 @default.
- W2766459926 hasConcept C86803240 @default.
- W2766459926 hasConcept C8891405 @default.
- W2766459926 hasConcept C89423630 @default.
- W2766459926 hasConceptScore W2766459926C134018914 @default.