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• W2766475448 abstract "Neuroblastoma (NB) often presents with metastatic disease and poor survival. The need for new prognostic markers remains invaluable. The FAK-Src-Paxillin protein system is associated with aggressive phenotype in adult malignancies but is largely unexplored in pediatric NB.To assess FAK-Src-Paxillin protein expression in human NB cell lines and clinical cytology material and to delineate its association with survival.Western blot and immunohistochemistry were applied for FAK-Src-Paxillin expression in NB cell lines and 23 human cytology specimens, respectively. Protein expression in human clinical samples was correlated with clinicopathological parameters, MYCN amplification and survival.FAK, Src and Paxillin proteins are expressed in human NB cells lines, and can be detected in clinical cytology specimens from NB patients, (59%, 32% and 33% respectively). Simultaneous FAK-Src-Paxillin expression was noted in 30% of NB patients. Children with concomitant positivity FAK, Src, and Paxillin tumors, as well as MYCN amplification, had increased mortality compared to those without.FAK-Src-Paxillin system is a marker of unfavorable prognosis for human NB patients but also a promising therapeutic target." @default.
• W2766475448 created "2017-11-10" @default.
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• W2766475448 date "2017-05-19" @default.
• W2766475448 modified "2023-10-18" @default.
• W2766475448 title "FAK-Src-paxillin system expression and disease outcome in human neuroblastoma" @default.
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• W2766475448 doi "https://doi.org/10.1080/08880018.2017.1360969" @default.
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