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• W2766480356 abstract "Panax ginseng has been used since ancient times based on the traditional Asian medicine theory and clinical experiences, and currently, is one of the most popular herbs in the world. To date, most of the studies concerning P. ginseng have focused on specific mechanisms of action of individual constituents. However, in spite of many studies on the molecular mechanisms of P. ginseng, it still remains unclear how multiple active ingredients of P. ginseng interact with multiple targets simultaneously, giving the multidimensional effects on various conditions and diseases. In order to decipher the systems-level mechanism of multiple ingredients of P. ginseng, a novel approach is needed beyond conventional reductive analysis. We aim to review the systems-level mechanism of P. ginseng by adopting novel analytical framework-network pharmacology. Here, we constructed a compound-target network of P. ginseng using experimentally validated and machine learning-based prediction results. The targets of the network were analyzed in terms of related biological process, pathways, and diseases. The majority of targets were found to be related with primary metabolic process, signal transduction, nitrogen compound metabolic process, blood circulation, immune system process, cell-cell signaling, biosynthetic process, and neurological system process. In pathway enrichment analysis of targets, mainly the terms related with neural activity showed significant enrichment and formed a cluster. Finally, relative degrees analysis for the target-disease association of P. ginseng revealed several categories of related diseases, including respiratory, psychiatric, and cardiovascular diseases." @default.
• W2766480356 created "2017-11-10" @default.
• W2766480356 creator A5018525747 @default.
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• W2766480356 creator A5035876514 @default.
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• W2766480356 creator A5071727338 @default.
• W2766480356 creator A5080018063 @default.
• W2766480356 creator A5091172204 @default.
• W2766480356 date "2018-01-01" @default.
• W2766480356 modified "2023-09-26" @default.
• W2766480356 title "Systems-level mechanisms of action of Panax ginseng: a network pharmacological approach" @default.
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• W2766480356 doi "https://doi.org/10.1016/j.jgr.2017.09.001" @default.
• W2766480356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5766701" @default.
• W2766480356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29348728" @default.
• W2766480356 hasPublicationYear "2018" @default.
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