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- W2766503583 abstract "Objective: To study the feasibility of (18)F-fluoro-L-dihydroxyphenylalanine positron emission tomography/Computed tomography ((18)F-DOPA PET/CT) scanning in the localization and differential diagnosing of focal versus diffuse form of pancreas lesions in patients with hyperinsulinemic hypoglycemia (HH). Method: Twenty-four patients were diagnosed with HH between January, 2016 and February, 2017 in the Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University using an integrated clinical and biochemical diagnostic protocol, domestic (18)F-DOPA PET/CT imaging technique were applied after MRI and ultrasound failed to detect pancreas lesions. Pancreas (18)F-DOPA standardized uptake values (SUV) were measured, and pancreas' lesions were dually analyzed via visual method and pancreas percentage SUV method. Among these patients, 9 patients received surgical pancreatic lesion resections, the correlations among surgical outcomes, histopathological findings and (18)F-DOPA PET/CT scan results were analyzed. Result: Seven patients were detected with focal form of pancreas lesions, the mean peak of SUV was 4.7±1.7(2.6-7.1), and 17 patients were found to have diffuse form lesions after (18)F-DOPA-PET/CT scanning. Among the 24 cases, 9 patients (7 showed focal and 2 showed diffuse (18)F-DOPA PET/CT pancreatic uptake)were euglycemic without any medical support after surgery; the resected pancreatic tissue histopathological results were consistent with that of PET/CT imaging. Only one patient, who responded to medical treatment before surgery, had temporary hyperglycemia after operation. Conclusion: Domestic (18)F-DOPA PET/CT could successfully locate and differentiate the pancreatic lesions and thus improve the success of surgery.目的： 初步分析国产(18)F－多巴正电子发射断层扫描((18)F－DOPA PET)/CT扫描区分高胰岛素血症性低血糖患儿胰腺不同类型病灶的可行性。 方法： 2016年1月至2017年2月复旦大学附属儿科医院内分泌遗传代谢科采用综合临床诊断流程诊断，经核磁共振成像扫描(MRI)和超声检查均未发现胰腺病灶的高胰岛素血症性低血糖患儿24例，采用国产(18)F－DOPA PET/CT扫描测定患儿胰腺各部位标准摄取值(SUV)，目测法和胰腺百分率法双重方法判别病灶类型，对其中选择手术的9例患儿，比较其手术转归、病理与扫描结果的相关性。 结果： (18)F－DOPA PET/CT扫描结果提示24例患儿中7例为胰腺局灶型病灶，SUV峰值为4.7±1.7(2.6～7.1), 17例为胰腺弥漫型病灶。其中9例患儿(局灶型病灶7例，弥漫型病灶2例)选择手术治疗，按照国产(18)F－DOPA PET/CT扫描结果进行手术，术后患儿均无低血糖发作，手术成功率100%，胰腺病理结果与国产(18)F－DOPA PET/CT扫描结果一致，仅1例胰腺弥漫型病灶患儿术后出现短暂高血糖。 结论： 国产(18)F－DOPA PET/CT扫描能够成功明确高胰岛素血症性低血糖患儿胰腺病灶位置，并区分病灶为局灶型或弥漫型，提高手术成功率。." @default.
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- W2766503583 date "2017-10-02" @default.
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- W2766503583 title "[Feasibility of domestic (18)F-DOPA PET/CT scanning in the differential diagnosis of pancreatic lesions in children with hyperinsulinemic hypoglycemia]." @default.
- W2766503583 doi "https://doi.org/10.3760/cma.j.issn.0578-1310.2017.10.015" @default.
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